MGP Database

MGP002926

Ontology/Pathway Information

Entrez Gene ID	6609
Gene Name	sphingomyelin phosphodiesterase 1, acid lysosomal
Gene Symbol	SMPD1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005768	IDA:UniProtKB	C	endosome
GO:0005615	IEA:Ensembl	C	extracellular space
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0042599	IEA:Ensembl	C	lamellar body
GO:0043202	TAS:Reactome	C	lysosomal lumen
GO:0005764	IDA:UniProtKB	C	lysosome
GO:0005886	IDA:UniProtKB	C	plasma membrane
GO:0016798	IEA:UniProtKB-KW	F	hydrolase activity, acting on glycosyl bonds
GO:0004767	TAS:ProtInc	F	sphingomyelin phosphodiesterase activity
GO:0046513	IMP:BHF-UCL	P	ceramide biosynthetic process
GO:0006687	TAS:Reactome	P	glycosphingolipid metabolic process
GO:0043407	IMP:BHF-UCL	P	negative regulation of MAP kinase activity
GO:0007399	TAS:ProtInc	P	nervous system development
GO:0043065	IEA:Ensembl	P	positive regulation of apoptotic process
GO:0035307	IMP:BHF-UCL	P	positive regulation of protein dephosphorylation
GO:0042220	IEA:Ensembl	P	response to cocaine
GO:0042493	IEA:Ensembl	P	response to drug
GO:0007165	TAS:ProtInc	P	signal transduction
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0006665	TAS:Reactome	P	sphingolipid metabolic process
GO:0006685	IEA:InterPro	P	sphingomyelin catabolic process
GO:0006684	TAS:ProtInc	P	sphingomyelin metabolic process
GO:0023021	IMP:BHF-UCL	P	termination of signal transduction

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_116105	Glycosphingolipid metabolism
REACT_111217	Metabolism
REACT_22258	Metabolism of lipids and lipoproteins
REACT_19323	Sphingolipid metabolism