MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002928

Record overview

MGPD IDMGP002928
Gene ID6611
SpeciesHomo sapiens (Human)
Gene Namespermine synthase
Gene Symbol SMS
SynonymsSRS; SpS; MRSR; SPMSY;
Alternate namesspermine synthase; spermidine aminopropyltransferase;
ChromosomeX
Map LocationXp22.1
EC Number2.5.1.22
SummaryThis gene encodes a protein belonging to the spermidine/spermin synthase family. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene are associated with X-linked Snyder-Robinson mental retardation syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
OrthologsView orthologs and multiple alignments for SMS

Proteins

spermine synthase isoform 1
Refseq ID:NP_004586
Protein GI:21264341
UniProt ID:P52788
mRNA ID:NM_004595
Length:366
RefSeq Status:
MAAARHSTLDFMLGAKADGETILKGLQSIFQEQGMAESVHTWQDHGYLATYTNKNGSFANLRIYPHGLVLLDLQSYDGDAQGKEEIDSILNKVEERMKEL
SQDSTGRVKRLPPIVRGGAIDRYWPTADGRLVEYDIDEVVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESDLAYTRAIMGSGKEDYTGKDVLILGGG
DGGILCEIVKLKPKMVTMVEIDQMVIDGCKKYMRKTCGDVLDNLKGDCYQVLIEDCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILD
LSMKVLKQDGKYFTQGNCVNLTEALSLYEEQLGRLYCPVEFSKEIVCVPSYLELWVFYTVWKKAKP
 
spermine synthase isoform 2
Refseq ID:NP_001245352
Protein GI:386643030
UniProt ID:P52788
mRNA ID:NM_001258423
Length:313
RefSeq Status:
MAAARHSTLDFMLGAKADGETILKGLQSIFQEQGMAESVHTWQDHGYLATYTNKNGRLPPIVRGGAIDRYWPTADGRLVEYDIDEVVYDEDSPYQNIKIL
HSKQFGNILILSGDVNLAESDLAYTRAIMGSGKEDYTGKDVLILGGGDGGILCEIVKLKPKMVTMVEIDQMVIDGCKKYMRKTCGDVLDNLKGDCYQVLI
EDCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILDLSMKVLKQDGKYFTQGNCVNLTEALSLYEEQLGRLYCPVEFSKEIVCVPSYLE
LWVFYTVWKKAKP
 
  logo