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MGP002953

UniProt Annotations

Entry Information
Gene Namesorbitol dehydrogenase
Protein EntryDHSO_HUMAN
UniProt IDQ00796
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q00796-1; Sequence=Displayed; Name=2; IsoId=Q00796-2; Sequence=VSP_056353, VSP_056354; Note=No experimental confirmation available.;
Catalytic ActivityL-iditol + NAD(+) = L-sorbose + NADH.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:12962626}; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:12962626};
FunctionConverts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm. {ECO:0000250|UniProtKB:Q64442}.
InductionUp-regulated by androgens and down-regulated by castration. {ECO:0000269|PubMed:20372835}.
MiscellaneousThe polyol pathway is proposed to be involved the cellular toxicity of diabetic hyperglycemia.
SimilarityBelongs to the zinc-containing alcohol dehydrogenase family. {ECO:0000305}.
Subcellular LocationMitochondrion membrane {ECO:0000250|UniProtKB:Q64442}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64442}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q64442}. Note=Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface. {ECO:0000250|UniProtKB:Q64442}.
SubunitHomotetramer. {ECO:0000269|PubMed:12962626}.
Tissue SpecificityExpressed in kidney and epithelial cells of both benign and malignant prostate tissue. Expressed in epididymis (at protein level). {ECO:0000269|PubMed:16278369, ECO:0000269|PubMed:19423711, ECO:0000269|PubMed:20372835}.
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