MGP Database

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MGP002954

Ontology/Pathway Information

Entrez Gene ID6654
Gene Nameson of sevenless homolog 1 (Drosophila)
Gene Symbol SOS1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0043025 IEA:EnsemblCneuronal cell body
GO:0005886 TAS:ReactomeCplasma membrane
GO:0014069 IEA:EnsemblCpostsynaptic density
GO:0003677 IEA:InterProFDNA binding
GO:0005088 EXP:ReactomeFRas guanyl-nucleotide exchange factor activity
GO:0005100 TAS:ProtIncFRho GTPase activator activity
GO:0005089 TAS:ProtIncFRho guanyl-nucleotide exchange factor activity
GO:0097190 TAS:ReactomePapoptotic signaling pathway
GO:0007411 TAS:ReactomePaxon guidance
GO:0007596 TAS:ReactomePblood coagulation
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0045087 TAS:ReactomePinnate immune response
GO:0008286 TAS:ReactomePinsulin receptor signaling pathway
GO:0050900 TAS:ReactomePleukocyte migration
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0030168 TAS:ReactomePplatelet activation
GO:0043065 TAS:ReactomePpositive regulation of apoptotic process
GO:0045742 IEA:EnsemblPpositive regulation of epidermal growth factor receptor signaling pathway
GO:0032320 EXP:GOCPpositive regulation of Ras GTPase activity
GO:0032321 TAS:GOCPpositive regulation of Rho GTPase activity
GO:0051057 IEA:EnsemblPpositive regulation of small GTPase mediated signal transduction
GO:0007265 TAS:ReactomePRas protein signal transduction
GO:0051056 TAS:ReactomePregulation of small GTPase mediated signal transduction
GO:0007165 NAS:ProtIncPsignal transduction
GO:0007264 TAS:ReactomePsmall GTPase mediated signal transduction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_19226Activation of Rac
REACT_75774Adaptive Immune System
REACT_118700Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
REACT_18266Axon guidance
REACT_13720Cell death signalling via NRAGE, NRIF and NADE
REACT_12051Cell surface interactions at the vascular wall
REACT_267817Constitutive Signaling by EGFRvIII
REACT_115852Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
REACT_75790Cytokine Signaling in Immune system
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_111045Developmental Biology
REACT_116125Disease
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_121096EGFR Transactivation by Gastrin
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163834FCERI mediated Ca+2 mobilization
REACT_163701FCERI mediated MAPK activation
REACT_21247FRS2-mediated cascade
REACT_18407G alpha (12/13) signalling events
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_19184GPCR downstream signaling
REACT_12606GRB2 events in EGFR signaling
REACT_115854GRB2 events in ERBB2 signaling
REACT_15443GRB2:SOS provides linkage to MAPK signaling for Integrins
REACT_604Hemostasis
REACT_150210IGF1R signaling cascade
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_1195Insulin receptor signalling cascade
REACT_15523Integrin alphaIIb beta3 signaling
REACT_27283Interleukin-2 signaling
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_23891Interleukin receptor SHC signaling
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_18334NCAM signaling for neurite out-growth
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_13638NRAGE signals death through JNK
REACT_13776p75 NTR receptor-mediated signalling
REACT_798Platelet activation, signaling and aggregation
REACT_278Platelet Aggregation (Plug Formation)
REACT_111225Regulation of KIT signaling
REACT_11051Rho GTPase cycle
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_12579SHC1 events in EGFR signaling
REACT_115993SHC1 events in ERBB2 signaling
REACT_116005SHC1 events in ERBB4 signaling
REACT_21374SHC-mediated cascade
REACT_661SHC-mediated signalling
REACT_999SHC-related events
REACT_150139SHC-related events triggered by IGF1R
REACT_508Signal attenuation
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_121398Signaling by FGFR mutants
REACT_14797Signaling by GPCR
REACT_498Signaling by Insulin receptor
REACT_22232Signaling by Interleukins
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_11044Signaling by Rho GTPases
REACT_19351Signaling by Robo receptor
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_11061Signalling by NGF
REACT_12058Signalling to ERKs
REACT_12033Signalling to RAS
REACT_111102Signal Transduction
REACT_524SOS-mediated signalling
REACT_12621Tie2 Signaling
SMP Pathway Links
SMP IDDescription
SMP00358Fc Epsilon Receptor I Signaling in Mast Cells
SMP00391Insulin Signalling
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