MGP Database

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MGP002957

Ontology/Pathway Information

Entrez Gene ID6667
Gene NameSp1 transcription factor
Gene Symbol SP1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IEA:UniProtKB-SubCellCcytoplasm
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IC:UniProtKBCnucleus
GO:0032993 IEA:EnsemblCprotein-DNA complex
GO:0043425 ISS:BHF-UCLFbHLH transcription factor binding
GO:0001046 ISS:UniProtKBFcore promoter sequence-specific DNA binding
GO:0003677 IDA:UniProtKBFDNA binding
GO:0003690 IDA:BHF-UCLFdouble-stranded DNA binding
GO:0035326 IEA:EnsemblFenhancer binding
GO:0042826 IPI:BHF-UCLFhistone deacetylase binding
GO:0071837 IPI:UniProtKBFHMG box domain binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0008022 IPI:UniProtKBFprotein C-terminus binding
GO:0042803 IDA:UniProtKBFprotein homodimerization activity
GO:0000978 ISS:BHF-UCLFRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IEA:EnsemblFRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0000979 IEA:EnsemblFRNA polymerase II core promoter sequence-specific DNA binding
GO:0001103 ISS:BHF-UCLFRNA polymerase II repressing transcription factor binding
GO:0043565 IDA:HGNCFsequence-specific DNA binding
GO:0000981 IBA:GO_CentralFsequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003700 IDA:UniProtKBFsequence-specific DNA binding transcription factor activity
GO:0008134 IPI:UniProtKBFtranscription factor binding
GO:0044212 IDA:BHF-UCLFtranscription regulatory region DNA binding
GO:0044255 TAS:ReactomePcellular lipid metabolic process
GO:0060216 IEA:EnsemblPdefinitive hemopoiesis
GO:0048596 IEA:EnsemblPembryonic camera-type eye morphogenesis
GO:0001892 IEA:EnsemblPembryonic placenta development
GO:0060136 IEA:EnsemblPembryonic process involved in female pregnancy
GO:0048706 IEA:EnsemblPembryonic skeletal system development
GO:0043353 IEA:EnsemblPenucleate erythrocyte differentiation
GO:0010467 TAS:ReactomePgene expression
GO:0001889 IEA:EnsemblPliver development
GO:0030324 IEA:EnsemblPlung development
GO:0030219 IEA:EnsemblPmegakaryocyte differentiation
GO:0001503 IEA:EnsemblPossification
GO:0043923 IDA:UniProtKBPpositive regulation by host of viral transcription
GO:0045893 IDA:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0006355 IDA:UniProtKBPregulation of transcription, DNA-templated
GO:0048511 IEA:UniProtKB-KWPrhythmic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006351 TAS:ReactomePtranscription, DNA-templated
GO:0006367 TAS:ReactomePtranscription initiation from RNA polymerase II promoter
GO:0007179 TAS:ReactomePtransforming growth factor beta receptor signaling pathway
GO:0001829 IEA:EnsemblPtrophectodermal cell differentiation
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_147904Activation of gene expression by SREBF (SREBP)
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_116125Disease
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_71Gene Expression
REACT_12627Generic Transcription Pathway
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_169325Oncogene Induced Senescence
REACT_116145PPARA activates gene expression
REACT_147797Regulation of cholesterol biosynthesis by SREBP (SREBF)
REACT_19241Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_111102Signal Transduction
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_120734SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
REACT_121061Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
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