MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002959

UniProt Annotations

Entry Information
Gene NameUDP-N-acetylglucosamine pyrophosphorylase 1
Protein EntryUAP1_HUMAN
UniProt IDQ16222
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=AGX2; Synonyms=AGX-2; IsoId=Q16222-1; Sequence=Displayed; Name=AGX1; Synonyms=AGX-1; IsoId=Q16222-2; Sequence=VSP_004483; Name=3; IsoId=Q16222-3; Sequence=VSP_014523;
Catalytic ActivityUTP + N-acetyl-alpha-D-galactosamine 1- phosphate = diphosphate + UDP-N-acetyl-alpha-D-galactosamine. {ECO:0000269|PubMed:9765219}.
Catalytic ActivityUTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + UDP-N-acetyl-alpha-D-glucosamine. {ECO:0000269|PubMed:9765219}.
FunctionConverts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.
PathwayNucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D- glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N- acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.
SimilarityBelongs to the UDPGP type 1 family. {ECO:0000305}.
Subcellular LocationCytoplasm. Note=In spermatozoa, localized to the principal piece of the tail, the neck region of the head and to a lesser extent, the midpiece of the tail.
SubunitMonomer and homodimer. Isoform AGX1 is a homodimer. Isoform AGX2 is a monomer. {ECO:0000269|PubMed:11707391}.
Tissue SpecificityWidely expressed. Isoform AGX1 is more abundant in testis than isoform AGX2, while isoform AGX2 is more abundant than isoform AGX1 in somatic tissue. Expressed at low level in placenta, muscle and liver.
  logo