MGP Database

MGP002964

Ontology/Pathway Information

Entrez Gene ID	6697
Gene Name	sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
Gene Symbol	SPR
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IDA:HPA	C	cytoplasm
GO:0005829	TAS:Reactome	C	cytosol
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0005739	IEA:Ensembl	C	mitochondrion
GO:0005654	IDA:HPA	C	nucleoplasm
GO:0004033	TAS:UniProtKB	F	aldo-keto reductase (NADP) activity
GO:0050661	TAS:UniProtKB	F	NADP binding
GO:0004757	ISS:UniProtKB	F	sepiapterin reductase activity
GO:0048667	IEA:Ensembl	P	cell morphogenesis involved in neuron differentiation
GO:0016265	IEA:Ensembl	P	death
GO:0042417	IEA:Ensembl	P	dopamine metabolic process
GO:0006558	IEA:Ensembl	P	L-phenylalanine metabolic process
GO:0006809	IDA:UniProtKB	P	nitric oxide biosynthetic process
GO:0046209	TAS:Reactome	P	nitric oxide metabolic process
GO:0042415	IEA:Ensembl	P	norepinephrine metabolic process
GO:0055114	TAS:UniProtKB	P	oxidation-reduction process
GO:0019889	IEA:Ensembl	P	pteridine metabolic process
GO:0040014	IEA:Ensembl	P	regulation of multicellular organism growth
GO:0050999	TAS:Reactome	P	regulation of nitric-oxide synthase activity
GO:0042428	IEA:Ensembl	P	serotonin metabolic process
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0006729	TAS:UniProtKB	P	tetrahydrobiopterin biosynthetic process
GO:0050882	IEA:Ensembl	P	voluntary musculoskeletal movement

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_12389	eNOS activation and regulation
REACT_111217	Metabolism
REACT_12508	Metabolism of nitric oxide
REACT_111176	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation

SMP Pathway Links

SMP ID	Description
SMP00486	Dopa-responsive dystonia
SMP00487	Hyperphenylalaniemia due to guanosine triphosphate cyclohydrolase deficiency
SMP00488	Hyperphenylalaninemia due to 6-pyruvoyltetrahydropterin synthase deficiency (ptps)
SMP00489	Hyperphenylalaninemia due to dhpr-deficiency
SMP00005	Pterine Biosynthesis
SMP00490	Segawa syndrome
SMP00491	Sepiapterin reductase deficiency