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MGP002968

UniProt Annotations

Entry Information
Gene Namespectrin, beta, non-erythrocytic 1
Protein EntrySPTB2_HUMAN
UniProt IDQ01082
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=Long; IsoId=Q01082-1; Sequence=Displayed; Name=Short; IsoId=Q01082-2; Sequence=VSP_000720, VSP_000721; Name=2; IsoId=Q01082-3; Sequence=VSP_026054, VSP_026055, VSP_026056; Note=Contains a phosphoserine at position 14.;
FunctionFodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
InteractionQ9NRI5:DISC1; NbExp=3; IntAct=EBI-351561, EBI-529989; P02549:SPTA1; NbExp=3; IntAct=EBI-351561, EBI-375617; Q13813:SPTAN1; NbExp=7; IntAct=EBI-351561, EBI-351450;
Sequence CautionSequence=BAD92985.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the spectrin family. {ECO:0000305}.
SimilarityContains 17 spectrin repeats. {ECO:0000305}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
SimilarityContains 2 CH (calponin-homology) domains. {ECO:0000255|PROSITE-ProRule:PRU00044}.
Subcellular LocationCytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}. Note=Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes. {ECO:0000250}.
Subcellular LocationIsoform 2: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
SubunitLike erythrocyte spectrin, the spectrin-like proteins are capable to form dimers which can further associate to tetramers. Interacts with CAMSAP1. Interacts with ANK2. Isoform Short cannot bind to the axonal protein fodaxin. {ECO:0000269|PubMed:15262991, ECO:0000269|PubMed:24117850}.
Tissue SpecificityIsoform 2 is present in brain, lung and kidney (at protein level). {ECO:0000269|PubMed:11665863}.
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