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MGP002970

UniProt Annotations

Entry Information
Gene Namesqualene epoxidase
Protein EntryERG1_HUMAN
UniProt IDQ14534
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivitySqualene + NADPH + O(2) = (3S)-2,3-epoxy-2,3- dihydrosqualene + NADP(+) + H(2)O.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692;
FunctionCatalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.
PathwayTerpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3.
SimilarityBelongs to the squalene monooxygenase family. {ECO:0000305}.
Subcellular LocationMicrosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
SubunitMay form a complex with squalene synthase.
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