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MGP002973

Record overview

MGPD IDMGP002973
Gene ID6716
SpeciesHomo sapiens (Human)
Gene Namesteroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
Gene Symbol SRD5A2
Alternate names3-oxo-5-alpha-steroid 4-dehydrogenase 2; 5 alpha-SR2; S5AR 2; SR type 2; steroid 5-alpha-reductase 2; type II 5-alpha reductase;
Chromosome2
Map Location2p23
EC Number1.3.1.22
SummaryThis gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for SRD5A2

Proteins

3-oxo-5-alpha-steroid 4-dehydrogenase 2
Refseq ID:NP_000339
Protein GI:39812447
UniProt ID:P31213
mRNA ID:NM_000348
Length:254
RefSeq Status:
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSL
LNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIE
WIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
 
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