MGP Database

MGP002975

Ontology/Pathway Information

Entrez Gene ID	6718
Gene Name	aldo-keto reductase family 1, member D1
Gene Symbol	AKR1D1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005829	IDA:UniProtKB	C	cytosol
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0047787	IEA:UniProtKB-EC	F	delta4-3-oxosteroid 5beta-reductase activity
GO:0005496	TAS:UniProtKB	F	steroid binding
GO:0008209	IDA:UniProtKB	P	androgen metabolic process
GO:0006699	IDA:UniProtKB	P	bile acid biosynthetic process
GO:0030573	IEA:UniProtKB-KW	P	bile acid catabolic process
GO:0008206	TAS:Reactome	P	bile acid metabolic process
GO:0008207	IDA:UniProtKB	P	C21-steroid hormone metabolic process
GO:0006707	IDA:UniProtKB	P	cholesterol catabolic process
GO:0007586	IDA:UniProtKB	P	digestion
GO:0055114	IDA:UniProtKB	P	oxidation-reduction process
GO:0044281	TAS:Reactome	P	small molecule metabolic process

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_11040	Bile acid and bile salt metabolism
REACT_111217	Metabolism
REACT_22258	Metabolism of lipids and lipoproteins
REACT_11054	Synthesis of bile acids and bile salts
REACT_11053	Synthesis of bile acids and bile salts via 24-hydroxycholesterol
REACT_11048	Synthesis of bile acids and bile salts via 27-hydroxycholesterol
REACT_11041	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

SMP Pathway Links

SMP ID	Description
SMP00575	11-beta-hydroxylase deficiency (CYP11B1)
SMP00566	17-alpha-hydroxylase deficiency (CYP17)
SMP00356	17-Beta Hydroxysteroid Dehydrogenase III Deficiency
SMP00576	21-hydroxylase deficiency (CYP21)
SMP00720	27-Hydroxylase Deficiency
SMP00718	3-Beta-Hydroxysteroid Dehydrogenase Deficiency
SMP00373	Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia due to 21-hydroxylase Deficiency
SMP00372	Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia due to 17 Alpha-hydroxylase Deficiency
SMP00068	Androgen and Estrogen Metabolism
SMP00717	Apparent mineralocorticoid excess syndrome
SMP00565	Aromatase deficiency
SMP00035	Bile Acid Biosynthesis
SMP00315	Cerebrotendinous Xanthomatosis (CTX)
SMP00314	Congenital Bile Acid Synthesis Defect Type II
SMP00318	Congenital Bile Acid Synthesis Defect Type III
SMP00371	Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH
SMP00577	Corticosterone methyl oxidase I deficiency (CMO I)
SMP00578	Corticosterone methyl oxidase II deficiency - CMO II
SMP00317	Familial Hypercholanemia (FHCA)
SMP00130	Steroidogenesis
SMP00316	Zellweger Syndrome