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MGP002995

Record overview

MGPD IDMGP002995
Gene ID6750
SpeciesHomo sapiens (Human)
Gene Namesomatostatin
Gene Symbol SST
SynonymsSMST;
Alternate namessomatostatin; growth hormone release-inhibiting factor; prepro-somatostatin; somatostatin-14; somatostatin-28;
Chromosome3
Map Location3q28
SummaryThe hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for SST

Proteins

somatostatin preproprotein
Refseq ID:NP_001039
Protein GI:4507243
UniProt ID:P61278
mRNA ID:NM_001048
Length:116
RefSeq Status:
MLSCRLQCALAALSIVLALGCVTGAPSDPRLRQFLQKSLAAAAGKQELAKYFLAELLSEPNQTENDALEPEDLSQAAEQDEMRLELQRSANSNPAMAPRE
RKAGCKNFFWKTFTSC
 
sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2407
peptide sequence: 
MLSCRLQCALAALSIVLALGCVTG

mat_peptide: 89..116
product: somatostatin-28
calculated_mol_wt: 3151
peptide sequence: 
SANSNPAMAPRERKAGCKNFFWKTFTSC

mat_peptide: 103..116
product: somatostatin-14
exception: alternative processing
calculated_mol_wt: 1640
peptide sequence: 
AGCKNFFWKTFTSC
 
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