MGP Database

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MGP003002

Ontology/Pathway Information

Entrez Gene ID6772
Gene Namesignal transducer and activator of transcription 1, 91kDa
Gene Symbol STAT1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0030424 ISS:UniProtKBCaxon
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0030425 ISS:UniProtKBCdendrite
GO:0000790 IDA:BHF-UCLCnuclear chromatin
GO:0005730 IDA:HPACnucleolus
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0005509 IEA:InterProFcalcium ion binding
GO:0003690 IDA:UniProtKBFdouble-stranded DNA binding
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0042803 IDA:UniProtKBFprotein homodimerization activity
GO:0000978 IDA:BHF-UCLFRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 IDA:BHF-UCLFRNA polymerase II core promoter sequence-specific DNA binding
GO:0000983 IDA:BHF-UCLFRNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0003700 IDA:UniProtKBFsequence-specific DNA binding transcription factor activity
GO:0004871 IEA:InterProFsignal transducer activity
GO:0005164 IPI:UniProtKBFtumor necrosis factor receptor binding
GO:0006915 ISS:UniProtKBPapoptotic process
GO:0008015 ISS:UniProtKBPblood circulation
GO:0032869 IEA:EnsemblPcellular response to insulin stimulus
GO:0035458 IMP:BHF-UCLPcellular response to interferon-beta
GO:0019221 TAS:ReactomePcytokine-mediated signaling pathway
GO:0051607 IEA:UniProtKB-KWPdefense response to virus
GO:0060333 ISS:UniProtKBPinterferon-gamma-mediated signaling pathway
GO:0007259 IDA:UniProtKBPJAK-STAT cascade
GO:0060397 TAS:ReactomePJAK-STAT cascade involved in growth hormone signaling pathway
GO:0031663 IEA:EnsemblPlipopolysaccharide-mediated signaling pathway
GO:0072162 ISS:UniProtKBPmetanephric mesenchymal cell differentiation
GO:0072136 ISS:UniProtKBPmetanephric mesenchymal cell proliferation involved in metanephros development
GO:0046725 IMP:AgBasePnegative regulation by virus of viral protein levels in host cell
GO:0016525 IMP:UniProtKBPnegative regulation of angiogenesis
GO:0001937 IMP:UniProtKBPnegative regulation of endothelial cell proliferation
GO:0043124 IMP:UniProtKBPnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0034240 IEA:EnsemblPnegative regulation of macrophage fusion
GO:0003340 ISS:UniProtKBPnegative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0072308 ISS:UniProtKBPnegative regulation of metanephric nephron tubule epithelial cell differentiation
GO:0000122 ISS:UniProtKBPnegative regulation of transcription from RNA polymerase II promoter
GO:0002053 ISS:UniProtKBPpositive regulation of mesenchymal cell proliferation
GO:0048661 ISS:UniProtKBPpositive regulation of smooth muscle cell proliferation
GO:0045893 IDA:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0042981 TAS:UniProtKBPregulation of apoptotic process
GO:0060334 TAS:ReactomePregulation of interferon-gamma-mediated signaling pathway
GO:0060338 TAS:ReactomePregulation of type I interferon-mediated signaling pathway
GO:0061326 IMP:UniProtKBPrenal tubule development
GO:0051591 ISS:UniProtKBPresponse to cAMP
GO:0034097 ISS:UniProtKBPresponse to cytokine
GO:0042493 IEA:EnsemblPresponse to drug
GO:0043330 IEA:EnsemblPresponse to exogenous dsRNA
GO:0042542 IEA:EnsemblPresponse to hydrogen peroxide
GO:0009612 IEA:EnsemblPresponse to mechanical stimulus
GO:0007584 IEA:EnsemblPresponse to nutrient
GO:0043434 ISS:UniProtKBPresponse to peptide hormone
GO:0006366 IDA:GOCPtranscription from RNA polymerase II promoter
GO:0033209 IDA:UniProtKBPtumor necrosis factor-mediated signaling pathway
GO:0060337 ISS:UniProtKBPtype I interferon signaling pathway
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_115676Antiviral mechanism by IFN-stimulated genes
REACT_75790Cytokine Signaling in Immune system
REACT_116125Disease
REACT_17025Downstream signal transduction
REACT_6900Immune System
REACT_25229Interferon Signaling
REACT_115831ISG15 antiviral mechanism
REACT_121141Signaling by FGFR1 fusion mutants
REACT_120999Signaling by FGFR1 mutants
REACT_120736Signaling by FGFR in disease
REACT_121398Signaling by FGFR mutants
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_111102Signal Transduction
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