MGP Database

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MGP003004

Ontology/Pathway Information

Entrez Gene ID6774
Gene Namesignal transducer and activator of transcription 3 (acute-phase response factor)
Gene Symbol STAT3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005743 IEA:EnsemblCmitochondrial inner membrane
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0005886 ISS:UniProtKBCplasma membrane
GO:0005509 IEA:InterProFcalcium ion binding
GO:0003677 ISS:UniProtKBFDNA binding
GO:0004879 IDA:BHF-UCLFligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0046983 ISS:UniProtKBFprotein dimerization activity
GO:0019901 ISS:UniProtKBFprotein kinase binding
GO:0019903 IPI:UniProtKBFprotein phosphatase binding
GO:0001103 IPI:BHF-UCLFRNA polymerase II repressing transcription factor binding
GO:0043565 IEA:EnsemblFsequence-specific DNA binding
GO:0003700 TAS:ProtIncFsequence-specific DNA binding transcription factor activity
GO:0004871 TAS:ProtIncFsignal transducer activity
GO:0008134 IPI:UniProtKBFtranscription factor binding
GO:0044212 IDA:BHF-UCLFtranscription regulatory region DNA binding
GO:0006953 IEA:EnsemblPacute-phase response
GO:0048708 ISS:UniProtKBPastrocyte differentiation
GO:0008283 IEA:EnsemblPcell proliferation
GO:0006928 TAS:ProtIncPcellular component movement
GO:0032870 IDA:BHF-UCLPcellular response to hormone stimulus
GO:0019221 NAS:UniProtKBPcytokine-mediated signaling pathway
GO:0042755 ISS:UniProtKBPeating behavior
GO:0001754 ISS:UniProtKBPeye photoreceptor cell differentiation
GO:0042593 ISS:UniProtKBPglucose homeostasis
GO:0060396 IDA:BHF-UCLPgrowth hormone receptor signaling pathway
GO:0070102 IDA:UniProtKBPinterleukin-6-mediated signaling pathway
GO:0030522 IDA:BHF-UCLPintracellular receptor signaling pathway
GO:0007259 TAS:UniProtKBPJAK-STAT cascade
GO:0060397 ISS:UniProtKBPJAK-STAT cascade involved in growth hormone signaling pathway
GO:0060548 IEA:EnsemblPnegative regulation of cell death
GO:0008285 IEA:EnsemblPnegative regulation of cell proliferation
GO:0045820 IEA:EnsemblPnegative regulation of glycolytic process
GO:2001223 IEA:EnsemblPnegative regulation of neuron migration
GO:0000122 TAS:ProtIncPnegative regulation of transcription from RNA polymerase II promoter
GO:0007399 TAS:ProtIncPnervous system development
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0016310 ISS:UniProtKBPphosphorylation
GO:0045747 ISS:UniProtKBPpositive regulation of Notch signaling pathway
GO:0045893 ISS:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:0006606 IDA:UniProtKBPprotein import into nucleus
GO:0060019 ISS:UniProtKBPradial glial cell differentiation
GO:0040014 IEA:EnsemblPregulation of multicellular organism growth
GO:0006355 IDA:UniProtKBPregulation of transcription, DNA-templated
GO:0006357 ISS:UniProtKBPregulation of transcription from RNA polymerase II promoter
GO:0042493 IEA:EnsemblPresponse to drug
GO:0032355 IDA:BHF-UCLPresponse to estradiol
GO:0045471 IEA:EnsemblPresponse to ethanol
GO:0019953 ISS:UniProtKBPsexual reproduction
GO:0007165 TAS:ProtIncPsignal transduction
GO:0019827 IEA:EnsemblPstem cell maintenance
GO:0001659 ISS:UniProtKBPtemperature homeostasis
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_75790Cytokine Signaling in Immune system
REACT_111045Developmental Biology
REACT_116125Disease
REACT_17025Downstream signal transduction
REACT_111133Growth hormone receptor signaling
REACT_6900Immune System
REACT_27307Interleukin-6 signaling
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_264617POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
REACT_169168Senescence-Associated Secretory Phenotype (SASP)
REACT_121141Signaling by FGFR1 fusion mutants
REACT_120999Signaling by FGFR1 mutants
REACT_120736Signaling by FGFR in disease
REACT_121398Signaling by FGFR mutants
REACT_22232Signaling by Interleukins
REACT_169118Signaling by Leptin
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_11061Signalling by NGF
REACT_12049Signalling to STAT3
REACT_111102Signal Transduction
REACT_263856Transcriptional regulation of pluripotent stem cells
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