MGP Database

MGP003006

Ontology/Pathway Information

Entrez Gene ID	6777
Gene Name	signal transducer and activator of transcription 5B
Gene Symbol	STAT5B
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	ISS:UniProtKB	C	cytoplasm
GO:0005829	TAS:Reactome	C	cytosol
GO:0005654	TAS:Reactome	C	nucleoplasm
GO:0005634	ISS:UniProtKB	C	nucleus
GO:0005509	IEA:InterPro	F	calcium ion binding
GO:0003682	ISS:UniProtKB	F	chromatin binding
GO:0003690	IEA:Ensembl	F	double-stranded DNA binding
GO:0035259	IPI:BHF-UCL	F	glucocorticoid receptor binding
GO:0046983	ISS:UniProtKB	F	protein dimerization activity
GO:0000979	IEA:Ensembl	F	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003700	TAS:ProtInc	F	sequence-specific DNA binding transcription factor activity
GO:0004871	IEA:Ensembl	F	signal transducer activity
GO:0006103	ISS:BHF-UCL	P	2-oxoglutarate metabolic process
GO:0006953	IEA:Ensembl	P	acute-phase response
GO:0000255	ISS:BHF-UCL	P	allantoin metabolic process
GO:0071364	ISS:UniProtKB	P	cellular response to epidermal growth factor stimulus
GO:0071363	ISS:UniProtKB	P	cellular response to growth factor stimulus
GO:0032870	IDA:BHF-UCL	P	cellular response to hormone stimulus
GO:0006101	ISS:BHF-UCL	P	citrate metabolic process
GO:0006600	ISS:BHF-UCL	P	creatine metabolic process
GO:0046449	ISS:BHF-UCL	P	creatinine metabolic process
GO:0046543	IEA:Ensembl	P	development of secondary female sexual characteristics
GO:0046544	IEA:Ensembl	P	development of secondary male sexual characteristics
GO:0006631	ISS:BHF-UCL	P	fatty acid metabolic process
GO:0007565	IEA:Ensembl	P	female pregnancy
GO:0006549	ISS:BHF-UCL	P	isoleucine metabolic process
GO:0007259	TAS:ProtInc	P	JAK-STAT cascade
GO:0060397	IDA:BHF-UCL	P	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0007595	IEA:Ensembl	P	lactation
GO:0019915	IEA:Ensembl	P	lipid storage
GO:0001889	IEA:Ensembl	P	liver development
GO:0001553	IEA:Ensembl	P	luteinization
GO:0001779	IEA:Ensembl	P	natural killer cell differentiation
GO:0043066	IEA:Ensembl	P	negative regulation of apoptotic process
GO:0045647	IEA:Ensembl	P	negative regulation of erythrocyte differentiation
GO:0006107	ISS:BHF-UCL	P	oxaloacetate metabolic process
GO:0048541	IEA:Ensembl	P	Peyer's patch development
GO:0042104	IEA:Ensembl	P	positive regulation of activated T cell proliferation
GO:0045579	IEA:Ensembl	P	positive regulation of B cell differentiation
GO:0051272	IEA:Ensembl	P	positive regulation of cellular component movement
GO:0045588	IEA:Ensembl	P	positive regulation of gamma-delta T cell differentiation
GO:0050729	IEA:Ensembl	P	positive regulation of inflammatory response
GO:0045086	IEA:Ensembl	P	positive regulation of interleukin-2 biosynthetic process
GO:0045931	IEA:Ensembl	P	positive regulation of mitotic cell cycle
GO:0040018	IEA:Ensembl	P	positive regulation of multicellular organism growth
GO:0032825	IEA:Ensembl	P	positive regulation of natural killer cell differentiation
GO:0045954	IEA:Ensembl	P	positive regulation of natural killer cell mediated cytotoxicity
GO:0032819	IEA:Ensembl	P	positive regulation of natural killer cell proliferation
GO:0048661	IEA:Ensembl	P	positive regulation of smooth muscle cell proliferation
GO:0045944	ISS:UniProtKB	P	positive regulation of transcription from RNA polymerase II promoter
GO:0042448	IEA:Ensembl	P	progesterone metabolic process
GO:0038161	ISS:UniProtKB	P	prolactin signaling pathway
GO:0030155	IEA:Ensembl	P	regulation of cell adhesion
GO:0030856	IEA:Ensembl	P	regulation of epithelial cell differentiation
GO:0040014	ISS:BHF-UCL	P	regulation of multicellular organism growth
GO:0019218	IEA:Ensembl	P	regulation of steroid metabolic process
GO:0006357	TAS:ProtInc	P	regulation of transcription from RNA polymerase II promoter
GO:0032355	IDA:BHF-UCL	P	response to estradiol
GO:0045471	IEA:Ensembl	P	response to ethanol
GO:0001666	IEA:Ensembl	P	response to hypoxia
GO:0070672	IEA:Ensembl	P	response to interleukin-15
GO:0070669	IEA:Ensembl	P	response to interleukin-2
GO:0070670	IEA:Ensembl	P	response to interleukin-4
GO:0032496	IEA:Ensembl	P	response to lipopolysaccharide
GO:0006105	ISS:BHF-UCL	P	succinate metabolic process
GO:0019530	ISS:BHF-UCL	P	taurine metabolic process
GO:0033077	IEA:Ensembl	P	T cell differentiation in thymus
GO:0043029	IEA:Ensembl	P	T cell homeostasis
GO:0006366	IEA:Ensembl	P	transcription from RNA polymerase II promoter
GO:0006573	ISS:BHF-UCL	P	valine metabolic process

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_75790	Cytokine Signaling in Immune system
REACT_116125	Disease
REACT_17025	Downstream signal transduction
REACT_111133	Growth hormone receptor signaling
REACT_6900	Immune System
REACT_27283	Interleukin-2 signaling
REACT_23837	Interleukin-3, 5 and GM-CSF signaling
REACT_115529	Interleukin-7 signaling
REACT_116022	Nuclear signaling by ERBB4
REACT_115697	Prolactin receptor signaling
REACT_115596	Signaling by ERBB4
REACT_121141	Signaling by FGFR1 fusion mutants
REACT_120999	Signaling by FGFR1 mutants
REACT_120736	Signaling by FGFR in disease
REACT_121398	Signaling by FGFR mutants
REACT_22232	Signaling by Interleukins
REACT_169118	Signaling by Leptin
REACT_16888	Signaling by PDGF
REACT_111040	Signaling by SCF-KIT
REACT_111102	Signal Transduction