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MGP003008

UniProt Annotations

Entry Information
Gene Namesulfotransferase family 1E, estrogen-preferring, member 1
Protein EntryST1E1_HUMAN
UniProt IDP49888
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate. {ECO:0000269|PubMed:11884392}.
FunctionSulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated. {ECO:0000269|PubMed:11884392}.
SimilarityBelongs to the sulfotransferase 1 family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer. {ECO:0000269|PubMed:11884392, ECO:0000269|PubMed:12782487}.
Tissue SpecificityLiver, intestine and at lower level in the kidney.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ste/";
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