MGP Database

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MGP003015

UniProt Annotations

Entry Information
Gene Namesulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
Protein EntryST1A2_HUMAN
UniProt IDP50226
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate. {ECO:0000269|PubMed:20417180}.
FunctionSulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.
SimilarityBelongs to the sulfotransferase 1 family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer. {ECO:0000250}.
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