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MGP003020

UniProt Annotations

Entry Information
Gene Namesulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
Protein EntryST1A1_HUMAN
UniProt IDP50225
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P50225-1; Sequence=Displayed; Name=2; IsoId=P50225-2; Sequence=VSP_040101; Note=No experimental confirmation available.;
Catalytic Activity3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate. {ECO:0000269|PubMed:12471039, ECO:0000269|PubMed:16221673, ECO:0000269|PubMed:21723874, ECO:0000269|PubMed:22069470}.
FunctionSulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk. {ECO:0000269|PubMed:12471039, ECO:0000269|PubMed:16221673}.
SimilarityBelongs to the sulfotransferase 1 family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer. {ECO:0000269|PubMed:12471039, ECO:0000269|PubMed:16221673, ECO:0000269|PubMed:20417180}.
Tissue SpecificityLiver, lung, adrenal, brain, platelets and skin.
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