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MGP003031

Record overview

MGPD IDMGP003031
Gene ID6839
SpeciesHomo sapiens (Human)
Gene Namesuppressor of variegation 3-9 homolog 1 (Drosophila)
Gene Symbol SUV39H1
SynonymsMG44; KMT1A; SUV39H; H3-K9-HMTase 1;
Alternate nameshistone-lysine N-methyltransferase SUV39H1; Su(var)3-9 homolog 1; histone H3-K9 methyltransferase 1; histone-lysine N-methyltransferase, H3 lysine-9 specific 1; lysine N-methyltransferase 1A; position-effect variegation 3-9 homolog;
ChromosomeX
Map LocationXp11.23
EC Number2.1.1.43
SummaryThis gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
OrthologsView orthologs and multiple alignments for SUV39H1

Proteins

histone-lysine N-methyltransferase SUV39H1 isoform 1
Refseq ID:NP_001269095
Protein GI:531990830
UniProt ID:O43463
mRNA ID:NM_001282166
Length:423
RefSeq Status:
MVGMSRLRNDRLADPLTGCSVCCKSSWNQLQDLCRLAKLSCPALGISKRNLYDFEVEYLCDYKKIREQEYYLVKWRGYPDSESTWEPRQNLKCVRILKQF
HKDLERELLRRHHRSKTPRHLDPSLANYLVQKAKQRRALRRWEQELNAKRSHLGRITVENEVDLDGPPRAFVYINEYRVGEGITLNQVAVGCECQDCLWA
PTGGCCPGASLHKFAYNDQGQVRLRAGLPIYECNSRCRCGYDCPNRVVQKGIRYDLCIFRTDDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQI
YDRQGATYLFDLDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGEELTFDYNMQVDPVDMESTRMDSNFGLAGLP
GSPKKRVRIECKCGTESCRKYLF
 
histone-lysine N-methyltransferase SUV39H1 isoform 2
Refseq ID:NP_003164
Protein GI:4507321
UniProt ID:O43463
mRNA ID:NM_003173
Length:412
RefSeq Status:
MAENLKGCSVCCKSSWNQLQDLCRLAKLSCPALGISKRNLYDFEVEYLCDYKKIREQEYYLVKWRGYPDSESTWEPRQNLKCVRILKQFHKDLERELLRR
HHRSKTPRHLDPSLANYLVQKAKQRRALRRWEQELNAKRSHLGRITVENEVDLDGPPRAFVYINEYRVGEGITLNQVAVGCECQDCLWAPTGGCCPGASL
HKFAYNDQGQVRLRAGLPIYECNSRCRCGYDCPNRVVQKGIRYDLCIFRTDDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFD
LDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGEELTFDYNMQVDPVDMESTRMDSNFGLAGLPGSPKKRVRIEC
KCGTESCRKYLF
 
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