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MGP003037

Record overview

MGPD IDMGP003037
Gene ID6850
SpeciesHomo sapiens (Human)
Gene Namespleen tyrosine kinase
Gene Symbol SYK
Synonymsp72-Syk;
Alternate namestyrosine-protein kinase SYK;
Chromosome9
Map Location9q22
EC Number2.7.10.2
SummaryThis gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
OrthologsView orthologs and multiple alignments for SYK

Proteins

tyrosine-protein kinase SYK isoform Syk(L)
Refseq ID:NP_003168
Protein GI:21361553
UniProt ID:P43405
mRNA ID:NM_003177
Length:635
RefSeq Status:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLV
CLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN
GSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVA
VKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNV
LLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
 
tyrosine-protein kinase SYK isoform Syk(L)
Refseq ID:NP_001167638
Protein GI:293332585
UniProt ID:P43405
mRNA ID:NM_001174167
Length:635
RefSeq Status:
Protein sequence is identical to GI:21361553 (mRNA isoform)
 
tyrosine-protein kinase SYK isoform Syk(S)
Refseq ID:NP_001128524
Protein GI:205277435
UniProt ID:P43405
mRNA ID:NM_001135052
Length:612
RefSeq Status:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLV
CLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN
GSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPASSPAQGNRQESTVSFNPY
EPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANV
MQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADE
NYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVE
LRLRNYYYDVVN
 
tyrosine-protein kinase SYK isoform Syk(S)
Refseq ID:NP_001167639
Protein GI:293332611
UniProt ID:P43405
mRNA ID:NM_001174168
Length:612
RefSeq Status:
Protein sequence is identical to GI:205277435 (mRNA isoform)
 
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