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MGP003060

Record overview

MGPD IDMGP003060
Gene ID6888
SpeciesHomo sapiens (Human)
Gene Nametransaldolase 1
Gene Symbol TALDO1
SynonymsTAL; TALH; TAL-H; TALDOR;
Alternate namestransaldolase; dihydroxyacetone transferase; glycerone transferase;
Chromosome11
Map Location11p15.5-p15.4
EC Number2.2.1.2;
SummaryTransaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for TALDO1

Proteins

transaldolase
Refseq ID:NP_006746
Protein GI:5803187
UniProt ID:P37837
mRNA ID:NM_006755
Length:337
RefSeq Status:
MSSSPVKRQRMESALDQLKQFTTVVADTGDFHAIDEYKPQDATTNPSLILAAAQMPAYQELVEEAIAYGRKLGGSQEDQIKNAIDKLFVLFGAEILKKIP
GRVSTEVDARLSFDKDAMVARARRLIELYKEAGISKDRILIKLSSTWEGIQAGKELEEQHGIHCNMTLLFSFAQAVACAEAGVTLISPFVGRILDWHVAN
TDKKSYEPLEDPGVKSVTKIYNYYKKFSYKTIVMGASFRNTGEIKALAGCDFLTISPKLLGELLQDNAKLVPVLSAKAAQASDLEKIHLDEKSFRWLHNE
DQMAVEKLSDGIRKFAADAVKLERMLTERMFNAENGK
 
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