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MGP003078

UniProt Annotations

Entry Information
Gene Nametranscription elongation factor A (SII), 1
Protein EntryTCEA1_HUMAN
UniProt IDP23193
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; IsoId=P23193-1; Sequence=Displayed; Name=2; IsoId=P23193-2; Sequence=VSP_006409;
DiseaseNote=A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1.
FunctionNecessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
InteractionQ8WVC0:LEO1; NbExp=4; IntAct=EBI-2608271, EBI-932432; Q8N7H5:PAF1; NbExp=4; IntAct=EBI-2608271, EBI-2607770;
MiscellaneousS-II binds to RNA-polymerase II in the absence of transcription.
SimilarityBelongs to the TFS-II family. {ECO:0000305}.
SimilarityContains 1 TFIIS central domain. {ECO:0000255|PROSITE- ProRule:PRU00651}.
SimilarityContains 1 TFIIS N-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00649}.
SimilarityContains 1 TFIIS-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00472}.
Subcellular LocationNucleus.
SubunitInteracts with EAF2 (By similarity). Associates with UBR5 and forms a transcription regulatory complex made of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription (e.g. gamma fibrinogen/FGG) by recruiting their promoters. {ECO:0000250, ECO:0000269|PubMed:21127351}.
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