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MGP003094

UniProt Annotations

Entry Information

Gene Name	t-complex 1
Protein Entry	TCPA_HUMAN
UniProt ID	P17987
Species	Human

Comments

Comment type	Description
Function	Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. {ECO:0000269\|PubMed:20080638}.
Interaction	P78380:OLR1; NbExp=5; IntAct=EBI-356553, EBI-7151999;
Similarity	Belongs to the TCP-1 chaperonin family. {ECO:0000305}.
Subcellular Location	Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Subunit	Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. {ECO:0000269\|PubMed:14532270, ECO:0000269\|PubMed:1630492, ECO:0000269\|PubMed:20080638}.