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MGP003099

Record overview

MGPD IDMGP003099
Gene ID7001
SpeciesHomo sapiens (Human)
Gene Nameperoxiredoxin 2
Gene Symbol PRDX2
SynonymsPRP; TSA; PRX2; PTX1; TPX1; NKEFB; PRXII; TDPX1; NKEF-B; HEL-S-2a;
Alternate namesperoxiredoxin-2; epididymis secretory sperm binding protein Li 2a; natural killer cell-enhancing factor B; thiol-specific antioxidant 1; thioredoxin peroxidase 1; thioredoxin-dependent peroxide reductase 1; torin;
Chromosome19
Map Location19p13.2
EC Number1.11.1.15
SummaryThis gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]
OrthologsView orthologs and multiple alignments for PRDX2

Proteins

peroxiredoxin-2
Refseq ID:NP_005800
Protein GI:32189392
UniProt ID:P32119
mRNA ID:NM_005809
Length:198
RefSeq Status:
MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYKGKYVVLFFYPLDFTFVCPTEIIAFSNRAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLN
IPLLADVTRRLSEDYGVLKTDEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN
 
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