MGP Database

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MGP003104

Ontology/Pathway Information

Entrez Gene ID7010
Gene NameTEK tyrosine kinase, endothelial
Gene Symbol TEK
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0016324 IDA:UniProtKBCapical plasma membrane
GO:0009925 IDA:UniProtKBCbasal plasma membrane
GO:0016323 IDA:UniProtKBCbasolateral plasma membrane
GO:0005911 IDA:UniProtKBCcell-cell junction
GO:0009986 IDA:UniProtKBCcell surface
GO:0005737 IEA:UniProtKB-KWCcytoplasm
GO:0005856 IEA:UniProtKB-SubCellCcytoskeleton
GO:0005576 IEA:UniProtKB-SubCellCextracellular region
GO:0005925 IEA:UniProtKB-SubCellCfocal adhesion
GO:0005887 IDA:UniProtKBCintegral component of plasma membrane
GO:0045121 IDA:UniProtKBCmembrane raft
GO:0005902 IDA:UniProtKBCmicrovillus
GO:0005886 TAS:ReactomeCplasma membrane
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0004672 TAS:ProtIncFprotein kinase activity
GO:0004713 IDA:UniProtKBFprotein tyrosine kinase activity
GO:0004872 TAS:ProtIncFreceptor activity
GO:0004714 TAS:ProtIncFtransmembrane receptor protein tyrosine kinase activity
GO:0001525 ISS:UniProtKBPangiogenesis
GO:0007596 TAS:ReactomePblood coagulation
GO:0007267 TAS:ProtIncPcell-cell signaling
GO:0007160 IEA:EnsemblPcell-matrix adhesion
GO:0060216 TAS:UniProtKBPdefinitive hemopoiesis
GO:0001958 IEA:EnsemblPendochondral ossification
GO:0001935 ISS:UniProtKBPendothelial cell proliferation
GO:0072012 ISS:UniProtKBPglomerulus vasculature development
GO:0007507 ISS:UniProtKBPheart development
GO:0060347 ISS:UniProtKBPheart trabecula formation
GO:0035556 IEA:EnsemblPintracellular signal transduction
GO:0050900 TAS:ReactomePleukocyte migration
GO:0016525 IMP:UniProtKBPnegative regulation of angiogenesis
GO:0043066 TAS:UniProtKBPnegative regulation of apoptotic process
GO:2000352 ISS:UniProtKBPnegative regulation of endothelial cell apoptotic process
GO:0050728 TAS:UniProtKBPnegative regulation of inflammatory response
GO:0031100 IEA:EnsemblPorgan regeneration
GO:0018108 IDA:UniProtKBPpeptidyl-tyrosine phosphorylation
GO:2000251 IMP:UniProtKBPpositive regulation of actin cytoskeleton reorganization
GO:0045766 IDA:UniProtKBPpositive regulation of angiogenesis
GO:0010595 IDA:UniProtKBPpositive regulation of endothelial cell migration
GO:0001938 TAS:UniProtKBPpositive regulation of endothelial cell proliferation
GO:0070374 IDA:UniProtKBPpositive regulation of ERK1 and ERK2 cascade
GO:0051894 IMP:UniProtKBPpositive regulation of focal adhesion assembly
GO:1902533 IMP:UniProtKBPpositive regulation of intracellular signal transduction
GO:0033138 IEA:EnsemblPpositive regulation of peptidyl-serine phosphorylation
GO:0043552 IMP:UniProtKBPpositive regulation of phosphatidylinositol 3-kinase activity
GO:0014068 IMP:UniProtKBPpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0051897 IDA:UniProtKBPpositive regulation of protein kinase B signaling
GO:0001934 IDA:UniProtKBPpositive regulation of protein phosphorylation
GO:0046777 IDA:UniProtKBPprotein autophosphorylation
GO:0051259 IDA:UniProtKBPprotein oligomerization
GO:2000351 TAS:UniProtKBPregulation of endothelial cell apoptotic process
GO:0032878 IMP:UniProtKBPregulation of establishment or maintenance of cell polarity
GO:0043114 TAS:UniProtKBPregulation of vascular permeability
GO:0051591 IEA:EnsemblPresponse to cAMP
GO:0043627 IEA:EnsemblPresponse to estrogen
GO:0001666 IEA:EnsemblPresponse to hypoxia
GO:0043434 IEA:EnsemblPresponse to peptide hormone
GO:0007165 TAS:ProtIncPsignal transduction
GO:0016337 IEA:EnsemblPsingle organismal cell-cell adhesion
GO:0002040 IMP:UniProtKBPsprouting angiogenesis
GO:0034446 IMP:UniProtKBPsubstrate adhesion-dependent cell spreading
GO:0048014 IDA:UniProtKBPTie signaling pathway
GO:0007169 IDA:UniProtKBPtransmembrane receptor protein tyrosine kinase signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_12051Cell surface interactions at the vascular wall
REACT_604Hemostasis
REACT_12621Tie2 Signaling
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