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MGP003108

UniProt Annotations

Entry Information
Gene Nametestis-specific kinase 1
Protein EntryTESK1_HUMAN
UniProt IDQ15569
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + a protein = ADP + a phosphoprotein.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
DomainThe extracatalytic C-terminal part is highly rich in proline residues.
Enzyme RegulationActivated by autophosphorylation on Ser-220. Kinase activity is inhibited by SPRED1 (By similarity). {ECO:0000250}.
FunctionDual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). {ECO:0000250}.
InteractionQ9C004:SPRY4; NbExp=4; IntAct=EBI-354852, EBI-354861;
PtmAutophosphorylated on serine and tyrosine residues. {ECO:0000250}.
SimilarityBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. {ECO:0000305}.
SimilarityContains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
SubunitInteracts with TAOK2; leading to inhibit TAOK2 activity. Interacts with SPRED1; leading to inhibit activity (By similarity). Interacts with SPRY4. {ECO:0000250, ECO:0000269|PubMed:12027893}.
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