MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003124

Ontology/Pathway Information

Entrez Gene ID7048
Gene Nametransforming growth factor, beta receptor II (70/80kDa)
Gene Symbol TGFBR2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005901 IDA:BHF-UCLCcaveola
GO:0005829 TAS:ReactomeCcytosol
GO:0009897 IDA:BHF-UCLCexternal side of plasma membrane
GO:0016021 IDA:BHF-UCLCintegral component of membrane
GO:0005886 TAS:ReactomeCplasma membrane
GO:0043235 IDA:BHF-UCLCreceptor complex
GO:0070022 IC:BHF-UCLCtransforming growth factor beta receptor homodimeric complex
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0005539 IDA:BHF-UCLFglycosaminoglycan binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0004702 IEA:InterProFreceptor signaling protein serine/threonine kinase activity
GO:0046332 IDA:BHF-UCLFSMAD binding
GO:0005024 IDA:BHF-UCLFtransforming growth factor beta-activated receptor activity
GO:0050431 IDA:BHF-UCLFtransforming growth factor beta binding
GO:0005026 IEA:InterProFtransforming growth factor beta receptor activity, type II
GO:0004675 IDA:BHF-UCLFtransmembrane receptor protein serine/threonine kinase activity
GO:0034714 IDA:BHF-UCLFtype III transforming growth factor beta receptor binding
GO:0034713 IDA:BHF-UCLFtype I transforming growth factor beta receptor binding
GO:0032147 ISS:BHF-UCLPactivation of protein kinase activity
GO:0007568 IEA:EnsemblPaging
GO:0006915 IDA:UniProtKBPapoptotic process
GO:0001568 TAS:BHF-UCLPblood vessel development
GO:0007420 ISS:BHF-UCLPbrain development
GO:0060434 IEA:EnsemblPbronchus morphogenesis
GO:0051216 IEA:EnsemblPcartilage development
GO:0007182 IEA:EnsemblPcommon-partner SMAD protein phosphorylation
GO:0007566 IEA:EnsemblPembryo implantation
GO:0048701 ISS:BHF-UCLPembryonic cranial skeleton morphogenesis
GO:0035162 ISS:BHF-UCLPembryonic hemopoiesis
GO:0007369 IEA:EnsemblPgastrulation
GO:0007507 ISS:BHF-UCLPheart development
GO:0001701 IEA:EnsemblPin utero embryonic development
GO:0002088 IEA:EnsemblPlens development in camera-type eye
GO:1990086 IEA:EnsemblPlens fiber cell apoptotic process
GO:0060463 IEA:EnsemblPlung lobe morphogenesis
GO:0060443 IEA:EnsemblPmammary gland morphogenesis
GO:0043011 ISS:BHF-UCLPmyeloid dendritic cell differentiation
GO:0060044 IEA:EnsemblPnegative regulation of cardiac muscle cell proliferation
GO:0030512 TAS:ReactomePnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0031100 IEA:EnsemblPorgan regeneration
GO:0060021 ISS:BHF-UCLPpalate development
GO:0060389 IDA:BHF-UCLPpathway-restricted SMAD protein phosphorylation
GO:0001569 ISS:BHF-UCLPpatterning of blood vessels
GO:0018105 IDA:BHF-UCLPpeptidyl-serine phosphorylation
GO:0018107 IDA:BHF-UCLPpeptidyl-threonine phosphorylation
GO:0045766 IEA:EnsemblPpositive regulation of angiogenesis
GO:0002663 ISS:BHF-UCLPpositive regulation of B cell tolerance induction
GO:0008284 TAS:ProtIncPpositive regulation of cell proliferation
GO:0010634 IEA:EnsemblPpositive regulation of epithelial cell migration
GO:0002053 ISS:BHF-UCLPpositive regulation of mesenchymal cell proliferation
GO:0051138 ISS:BHF-UCLPpositive regulation of NK T cell differentiation
GO:2000379 IMP:BHF-UCLPpositive regulation of reactive oxygen species metabolic process
GO:0043415 IEA:EnsemblPpositive regulation of skeletal muscle tissue regeneration
GO:0048661 IEA:EnsemblPpositive regulation of smooth muscle cell proliferation
GO:0002666 ISS:BHF-UCLPpositive regulation of T cell tolerance induction
GO:0002651 ISS:BHF-UCLPpositive regulation of tolerance induction to self antigen
GO:0006468 IDA:BHF-UCLPprotein phosphorylation
GO:0006898 IEA:EnsemblPreceptor-mediated endocytosis
GO:0042127 ISS:BHF-UCLPregulation of cell proliferation
GO:0070723 IDA:BHF-UCLPresponse to cholesterol
GO:0042493 IDA:BHF-UCLPresponse to drug
GO:0043627 IEA:EnsemblPresponse to estrogen
GO:0009749 IEA:EnsemblPresponse to glucose
GO:0009612 IEA:EnsemblPresponse to mechanical stimulus
GO:0007584 IEA:EnsemblPresponse to nutrient
GO:0007224 IEA:EnsemblPsmoothened signaling pathway
GO:0060440 IEA:EnsemblPtrachea formation
GO:0007179 IDA:BHF-UCLPtransforming growth factor beta receptor signaling pathway
GO:0001570 ISS:BHF-UCLPvasculogenesis
GO:0042060 IEA:EnsemblPwound healing
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_116125Disease
REACT_120727Downregulation of TGF-beta receptor signaling
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_111102Signal Transduction
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_120850TGF-beta receptor signaling activates SMADs
REACT_120726TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
  logo