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MGP003129

UniProt Annotations

Entry Information
Gene Namethrombospondin 2
Protein EntryTSP2_HUMAN
UniProt IDP35442
SpeciesHuman
Comments
Comment typeDescription
DiseaseIntervertebral disc disease (IDD) [MIM:603932]: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. {ECO:0000269|PubMed:18455130}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
FunctionAdhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties. {ECO:0000269|PubMed:20714802}.
InteractionP54290:Cacna2d1 (xeno); NbExp=2; IntAct=EBI-2466249, EBI-2466294;
SimilarityBelongs to the thrombospondin family. {ECO:0000305}.
SimilarityContains 1 laminin G-like domain. {ECO:0000305}.
SimilarityContains 1 TSP C-terminal (TSPC) domain. {ECO:0000255|PROSITE-ProRule:PRU00635}.
SimilarityContains 1 VWFC domain. {ECO:0000255|PROSITE- ProRule:PRU00220}.
SimilarityContains 2 EGF-like domains. {ECO:0000255|PROSITE- ProRule:PRU00076}.
SimilarityContains 3 TSP type-1 domains. {ECO:0000255|PROSITE- ProRule:PRU00210}.
SimilarityContains 8 TSP type-3 repeats. {ECO:0000255|PROSITE- ProRule:PRU00634}.
SubunitHomotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS2 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin and type V collagen. {ECO:0000250, ECO:0000269|PubMed:11590138, ECO:0000269|PubMed:1371676, ECO:0000269|PubMed:16186819}.
Tissue SpecificityHigh expression in invertebral disk tissue. {ECO:0000269|PubMed:18455130}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/THBS2ID42549ch6q27.html";
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