MGP Database

MGP003140

Record overview

MGPD ID	MGP003140
Gene ID	7084
Species	Homo sapiens (Human)
Gene Name	thymidine kinase 2, mitochondrial
Gene Symbol	TK2
Synonyms	MTTK; SCA31; MTDPS2;
Alternate names	thymidine kinase 2, mitochondrial; mt-TK;
Chromosome	16
Map Location	16q22-q23.1
Summary	This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012]
Orthologs	View orthologs and multiple alignments for TK2

Proteins

thymidine kinase 2 isoform 2

Refseq ID:	NP_001166114
Protein GI:	290656975
UniProt ID:	O00142
mRNA ID:	NM_001172643
Length:	234
RefSeq Status:

`MGAFCQRPSSDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRL MERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAP VLVIEADHHMERMLELFEQNRDRILTPENRKHCP`

transit_peptide: 1..33
calculated_mol_wt: 3535
peptide sequence: 
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRR

mat_peptide: 34..265
product: thymidine kinase 2, mitochondrial isoform 1
calculated_mol_wt: 27488
peptide sequence: 
VQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLME
RSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVL
VIEADHHMERMLELFEQNRDRILTPENRKHCP

transit_peptide: 1..46
calculated_mol_wt: 5552
peptide sequence: 
MYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIF

mat_peptide: 47..168
product: thymidine kinase 2, mitochondrial isoform 7
calculated_mol_wt: 14747
peptide sequence: 
VENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMER
MLELFEQNRDRILTPENRKHCP

thymidine kinase 2 isoform 5

Refseq ID:	NP_001258863
Protein GI:	429836851
UniProt ID:	Q8IZR3
mRNA ID:	NM_001271934
Length:	216
RefSeq Status:

`MTSICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYR SGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFE QNRDRILTPENRKHCP`

transit_peptide: 1..33
calculated_mol_wt: 3535
peptide sequence: 
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRR

mat_peptide: 34..265
product: thymidine kinase 2, mitochondrial isoform 1
calculated_mol_wt: 27488
peptide sequence: 
VQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLME
RSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVL
VIEADHHMERMLELFEQNRDRILTPENRKHCP

transit_peptide: 1..46
calculated_mol_wt: 5552
peptide sequence: 
MYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIF

mat_peptide: 47..168
product: thymidine kinase 2, mitochondrial isoform 7
calculated_mol_wt: 14747
peptide sequence: 
VENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMER
MLELFEQNRDRILTPENRKHCP

thymidine kinase 2 isoform 6

Refseq ID:	NP_001258864
Protein GI:	429836854
UniProt ID:	O00142
mRNA ID:	NM_001271935
Length:	146
RefSeq Status:

`MGAFCQRPSSDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRL MERSIHSARYIFVENLYRRNTWKQFTISMRSGSSKAAFSPWQPLFW`

transit_peptide: 1..33
calculated_mol_wt: 3535
peptide sequence: 
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRR

mat_peptide: 34..265
product: thymidine kinase 2, mitochondrial isoform 1
calculated_mol_wt: 27488
peptide sequence: 
VQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLME
RSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVL
VIEADHHMERMLELFEQNRDRILTPENRKHCP

transit_peptide: 1..46
calculated_mol_wt: 5552
peptide sequence: 
MYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIF

mat_peptide: 47..168
product: thymidine kinase 2, mitochondrial isoform 7
calculated_mol_wt: 14747
peptide sequence: 
VENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMER
MLELFEQNRDRILTPENRKHCP

transit_peptide: 1..33
calculated_mol_wt: 3535
peptide sequence: 
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRR

mat_peptide: 34..247
product: thymidine kinase 2, mitochondrial isoform 4
calculated_mol_wt: 25403
peptide sequence: 
VQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRSG
KMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQN
RDRILTPENRKHCP

transit_peptide: 1..33
calculated_mol_wt: 3535
peptide sequence: 
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRR

mat_peptide: 34..240
product: thymidine kinase 2, mitochondrial isoform 3
calculated_mol_wt: 24857
peptide sequence: 
VQRRAWPPDKEQEKEKKSVVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDY
VVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTP
ENRKHCP

thymidine kinase 2, mitochondrial isoform 1 precursor

Refseq ID:	NP_004605
Protein GI:	290656936
UniProt ID:	O00142
mRNA ID:	NM_004614
Length:	265
RefSeq Status:

`MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYH DASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREE EKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP`

transit_peptide: 1..33
calculated_mol_wt: 3535
peptide sequence: 
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRR

mat_peptide: 34..265
product: thymidine kinase 2, mitochondrial isoform 1
calculated_mol_wt: 27488
peptide sequence: 
VQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLME
RSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVL
VIEADHHMERMLELFEQNRDRILTPENRKHCP

thymidine kinase 2, mitochondrial isoform 3 precursor

Refseq ID:	NP_001166115
Protein GI:	290657146
UniProt ID:	O00142
mRNA ID:	NM_001172644
Length:	240
RefSeq Status:

`MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQ VSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSL FPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP`

transit_peptide: 1..33
calculated_mol_wt: 3535
peptide sequence: 
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRR

mat_peptide: 34..265
product: thymidine kinase 2, mitochondrial isoform 1
calculated_mol_wt: 27488
peptide sequence: 
VQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLME
RSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVL
VIEADHHMERMLELFEQNRDRILTPENRKHCP

transit_peptide: 1..46
calculated_mol_wt: 5552
peptide sequence: 
MYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIF

mat_peptide: 47..168
product: thymidine kinase 2, mitochondrial isoform 7
calculated_mol_wt: 14747
peptide sequence: 
VENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMER
MLELFEQNRDRILTPENRKHCP

transit_peptide: 1..33
calculated_mol_wt: 3535
peptide sequence: 
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRR

mat_peptide: 34..247
product: thymidine kinase 2, mitochondrial isoform 4
calculated_mol_wt: 25403
peptide sequence: 
VQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRSG
KMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQN
RDRILTPENRKHCP

transit_peptide: 1..33
calculated_mol_wt: 3535
peptide sequence: 
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRR

mat_peptide: 34..240
product: thymidine kinase 2, mitochondrial isoform 3
calculated_mol_wt: 24857
peptide sequence: 
VQRRAWPPDKEQEKEKKSVVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDY
VVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTP
ENRKHCP

thymidine kinase 2, mitochondrial isoform 4 precursor

Refseq ID:	NP_001166116
Protein GI:	290657203
UniProt ID:	Q8IZR3
mRNA ID:	NM_001172645
Length:	247
RefSeq Status:

`MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEGLMYHDASRWGLTLQTYVQLTML DRHTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEE WLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP`

transit_peptide: 1..33
calculated_mol_wt: 3535
peptide sequence: 
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRR

mat_peptide: 34..265
product: thymidine kinase 2, mitochondrial isoform 1
calculated_mol_wt: 27488
peptide sequence: 
VQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLME
RSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVL
VIEADHHMERMLELFEQNRDRILTPENRKHCP

transit_peptide: 1..46
calculated_mol_wt: 5552
peptide sequence: 
MYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIF

mat_peptide: 47..168
product: thymidine kinase 2, mitochondrial isoform 7
calculated_mol_wt: 14747
peptide sequence: 
VENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMER
MLELFEQNRDRILTPENRKHCP

transit_peptide: 1..33
calculated_mol_wt: 3535
peptide sequence: 
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRR

mat_peptide: 34..247
product: thymidine kinase 2, mitochondrial isoform 4
calculated_mol_wt: 25403
peptide sequence: 
VQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRSG
KMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQN
RDRILTPENRKHCP

thymidine kinase 2, mitochondrial isoform 7 precursor

Refseq ID:	NP_001258979
Protein GI:	440309859
UniProt ID:	O00142
mRNA ID:	NM_001272050
Length:	168
RefSeq Status:

`MYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRC REEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP`

transit_peptide: 1..33
calculated_mol_wt: 3535
peptide sequence: 
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRR

mat_peptide: 34..265
product: thymidine kinase 2, mitochondrial isoform 1
calculated_mol_wt: 27488
peptide sequence: 
VQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLME
RSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVL
VIEADHHMERMLELFEQNRDRILTPENRKHCP

transit_peptide: 1..46
calculated_mol_wt: 5552
peptide sequence: 
MYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIF

mat_peptide: 47..168
product: thymidine kinase 2, mitochondrial isoform 7
calculated_mol_wt: 14747
peptide sequence: 
VENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMER
MLELFEQNRDRILTPENRKHCP