MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003141

UniProt Annotations

Entry Information
Gene Nametransketolase
Protein EntryTKT_HUMAN
UniProt IDP29401
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P29401-1; Sequence=Displayed; Name=2; IsoId=P29401-2; Sequence=VSP_045566; Note=No experimental confirmation available.;
Catalytic ActivitySedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:3248678}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000269|PubMed:3248678}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:3248678}; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000269|PubMed:3248678}; Note=Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+). {ECO:0000269|PubMed:3248678};
CofactorName=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000269|PubMed:3248678}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO:0000269|PubMed:3248678};
FunctionCatalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
SimilarityBelongs to the transketolase family. {ECO:0000305}.
SubunitHomodimer.
Web ResourceName=Wikipedia; Note=Transketolase entry; URL="http://en.wikipedia.org/wiki/Transketolase";
  logo