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MGP003142

UniProt Annotations

Entry Information
Gene Nametransducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
FunctionTranscriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. {ECO:0000269|PubMed:10660609}.
InteractionSelf; NbExp=4; IntAct=EBI-711424, EBI-711424; P62805:HIST2H4B; NbExp=6; IntAct=EBI-711424, EBI-302023; Q01196-1:RUNX1; NbExp=4; IntAct=EBI-711424, EBI-925940; Q01196-2:RUNX1; NbExp=3; IntAct=EBI-711424, EBI-925944; Q13761:RUNX3; NbExp=3; IntAct=EBI-711424, EBI-925990; Q96EB6:SIRT1; NbExp=4; IntAct=EBI-711424, EBI-1802965; A4PIW0:SYT-SSX2; NbExp=11; IntAct=EBI-711424, EBI-6050533;
PtmPhosphorylated, probably by CDK1. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1. {ECO:0000269|PubMed:21406692}.
PtmUbiquitinated by XIAP/BIRC4. {ECO:0000269|PubMed:22304967}.
SimilarityBelongs to the WD repeat Groucho/TLE family. {ECO:0000305}.
SimilarityContains 6 WD repeats. {ECO:0000255|PROSITE- ProRule:PRU00221}.
Subcellular LocationNucleus {ECO:0000269|PubMed:12397081}. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.
SubunitHomooligomer and heterooligomer with other family members. Binds LEF1, RUNX1, RUNX3, FOXA2, KDM6A, UTY, histone H3, HESX1, ESRRG and the NF-kappa-B subunit RELA. Interacts with HES1 (via WRPW motif). Interacts with SIX3. {ECO:0000269|PubMed:10660609, ECO:0000269|PubMed:10748198, ECO:0000269|PubMed:11731482, ECO:0000269|PubMed:12441302, ECO:0000269|PubMed:14651967, ECO:0000269|PubMed:8649374, ECO:0000269|PubMed:8687460, ECO:0000269|PubMed:9334241, ECO:0000269|PubMed:9751710, ECO:0000269|PubMed:9854018, ECO:0000269|PubMed:9874198}.
Tissue SpecificityIn all tissues examined, mostly in brain, liver and muscle.
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