MGP Database

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MGP003145

UniProt Annotations

Entry Information
Gene Nametransducin-like enhancer of split 4
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q04727-1; Sequence=Displayed; Name=2; IsoId=Q04727-2; Sequence=VSP_030497; Note=No experimental confirmation available.; Name=3; IsoId=Q04727-3; Sequence=VSP_030498; Note=No experimental confirmation available.; Name=4; IsoId=Q04727-4; Sequence=VSP_055169;
FunctionTranscriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). {ECO:0000250}.
PtmPhosphorylated. PAX5 binding increases phosphorylation (By similarity). {ECO:0000250}.
PtmUbiquitinated by XIAP/BIRC4. {ECO:0000269|PubMed:22304967}.
Sequence CautionSequence=BAA86575.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC22598.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAC22599.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13644.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13734.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41315.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the WD repeat Groucho/TLE family. {ECO:0000305}.
SimilarityContains 7 WD repeats. {ECO:0000255|PROSITE- ProRule:PRU00221}.
Subcellular LocationNucleus.
SubunitHomooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2. Interacts with ZNF703; TLE4 may mediate ZNF703 transcriptional repression. Interacts with SIX3 and SIX6 (By similarity). Interacts with PAX2. {ECO:0000250, ECO:0000269|PubMed:24676634}.
Tissue SpecificityIn all tissues examined, mostly in brain, and muscle.
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