MGP Database

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MGP003151

Ontology/Pathway Information

Entrez Gene ID7099
Gene Nametoll-like receptor 4
Gene Symbol TLR4
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:BHF-UCLCcytoplasm
GO:0010008 TAS:ReactomeCendosome membrane
GO:0009897 IDA:BHF-UCLCexternal side of plasma membrane
GO:0005887 IDA:UniProtKBCintegral component of plasma membrane
GO:0046696 IDA:UniProtKBClipopolysaccharide receptor complex
GO:0048471 IDA:UniProtKBCperinuclear region of cytoplasm
GO:0005886 IDA:BHF-UCLCplasma membrane
GO:0001530 NAS:UniProtKBFlipopolysaccharide binding
GO:0001875 IDA:UniProtKBFlipopolysaccharide receptor activity
GO:0004872 TAS:ProtIncFreceptor activity
GO:0004888 NAS:UniProtKBFtransmembrane signaling receptor activity
GO:0000187 ISS:BHF-UCLPactivation of MAPK activity
GO:0002322 IEA:EnsemblPB cell proliferation involved in immune response
GO:0071222 ISS:BHF-UCLPcellular response to lipopolysaccharide
GO:0071223 IEA:EnsemblPcellular response to lipoteichoic acid
GO:0071260 IEP:UniProtKBPcellular response to mechanical stimulus
GO:0042742 TAS:UniProtKBPdefense response to bacterium
GO:0050829 IC:BHF-UCLPdefense response to Gram-negative bacterium
GO:0016046 NAS:UniProtKBPdetection of fungus
GO:0032497 IDA:UniProtKBPdetection of lipopolysaccharide
GO:0007249 TAS:ReactomePI-kappaB kinase/NF-kappaB signaling
GO:0007252 IDA:BHF-UCLPI-kappaB phosphorylation
GO:0006955 TAS:ProtIncPimmune response
GO:0045087 TAS:BHF-UCLPinnate immune response
GO:0032609 IEA:EnsemblPinterferon-gamma production
GO:0060729 ISS:BHF-UCLPintestinal epithelial structure maintenance
GO:0031663 IGI:MGIPlipopolysaccharide-mediated signaling pathway
GO:0042116 IMP:UniProtKBPmacrophage activation
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0070373 ISS:BHF-UCLPnegative regulation of ERK1 and ERK2 cascade
GO:0032689 ISS:BHF-UCLPnegative regulation of interferon-gamma production
GO:0032700 ISS:BHF-UCLPnegative regulation of interleukin-17 production
GO:0032707 ISS:BHF-UCLPnegative regulation of interleukin-23 production
GO:0032715 ISS:BHF-UCLPnegative regulation of interleukin-6 production
GO:0045671 NAS:UniProtKBPnegative regulation of osteoclast differentiation
GO:0032720 ISS:BHF-UCLPnegative regulation of tumor necrosis factor production
GO:0002537 IEA:EnsemblPnitric oxide production involved in inflammatory response
GO:0030890 IEA:EnsemblPpositive regulation of B cell proliferation
GO:0032722 IDA:BHF-UCLPpositive regulation of chemokine production
GO:0070374 IEA:EnsemblPpositive regulation of ERK1 and ERK2 cascade
GO:0050729 IC:BHF-UCLPpositive regulation of inflammatory response
GO:0032727 ISS:BHF-UCLPpositive regulation of interferon-alpha production
GO:0045359 IEA:EnsemblPpositive regulation of interferon-beta biosynthetic process
GO:0032728 ISS:BHF-UCLPpositive regulation of interferon-beta production
GO:0032729 ISS:BHF-UCLPpositive regulation of interferon-gamma production
GO:0032733 ISS:BHF-UCLPpositive regulation of interleukin-10 production
GO:0045084 IDA:UniProtKBPpositive regulation of interleukin-12 biosynthetic process
GO:0032735 ISS:BHF-UCLPpositive regulation of interleukin-12 production
GO:0032732 ISS:BHF-UCLPpositive regulation of interleukin-1 production
GO:0032755 IDA:BHF-UCLPpositive regulation of interleukin-6 production
GO:0045416 IDA:UniProtKBPpositive regulation of interleukin-8 biosynthetic process
GO:0032757 IDA:BHF-UCLPpositive regulation of interleukin-8 production
GO:0046330 IEA:EnsemblPpositive regulation of JNK cascade
GO:0060907 IEA:EnsemblPpositive regulation of macrophage cytokine production
GO:0045348 IEA:EnsemblPpositive regulation of MHC class II biosynthetic process
GO:0042346 IDA:BHF-UCLPpositive regulation of NF-kappaB import into nucleus
GO:0051092 IDA:MGIPpositive regulation of NF-kappaB transcription factor activity
GO:0045429 IEA:EnsemblPpositive regulation of nitric oxide biosynthetic process
GO:0051770 ISS:BHF-UCLPpositive regulation of nitric-oxide synthase biosynthetic process
GO:0070430 IEA:EnsemblPpositive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070434 IEA:EnsemblPpositive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0010572 ISS:BHF-UCLPpositive regulation of platelet activation
GO:0045944 ISS:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:0042535 IDA:UniProtKBPpositive regulation of tumor necrosis factor biosynthetic process
GO:0032760 ISS:BHF-UCLPpositive regulation of tumor necrosis factor production
GO:0050707 IEA:InterProPregulation of cytokine secretion
GO:0032496 IC:BHF-UCLPresponse to lipopolysaccharide
GO:0042088 NAS:UniProtKBPT-helper 1 type immune response
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_25148Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
REACT_25374IKK complex recruitment mediated by RIP1
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25351TRAF6 mediated induction of TAK1 complex
REACT_150361TRIF-mediated programmed cell death
REACT_25281TRIF-mediated TLR3/TLR4 signaling
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