MGP Database

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MGP003154

UniProt Annotations

Entry Information
Gene Nametransmembrane 7 superfamily member 2
Protein EntryERG24_HUMAN
UniProt IDO76062
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O76062-1; Sequence=Displayed; Name=2; IsoId=O76062-2; Sequence=VSP_017898; Note=No experimental confirmation available.;
Catalytic Activity4,4-dimethyl-5-alpha-cholesta-8,24-dien-3- beta-ol + NADP(+) = 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3- beta-ol + NADPH.
FunctionInvolved in the conversion of lanosterol to cholesterol. {ECO:0000269|PubMed:11784322}.
Sequence CautionSequence=AAC21450.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=AAC21457.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
SimilarityBelongs to the ERG4/ERG24 family. {ECO:0000305}.
Subcellular LocationMicrosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:9878250}; Multi-pass membrane protein {ECO:0000269|PubMed:9878250}.
Tissue SpecificityExpressed in adult heart, brain, pancreas, lung, liver, skeletal muscle, kidney, ovary, prostate, and testis, but not detected in placenta, spleen, thymus, small intestine, colon (mucosal lining), or peripheral blood leukocytes. {ECO:0000269|PubMed:9878250}.
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