MGP Database

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MGP003158

Ontology/Pathway Information

Entrez Gene ID7124
Gene Nametumor necrosis factor
Gene Symbol TNF
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0009986 IDA:BHF-UCLCcell surface
GO:0009897 ISS:BHF-UCLCexternal side of plasma membrane
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IDA:BHF-UCLCextracellular space
GO:0005887 IDA:BHF-UCLCintegral component of plasma membrane
GO:0045121 IDA:BHF-UCLCmembrane raft
GO:0001891 ISS:BHF-UCLCphagocytic cup
GO:0005886 TAS:ReactomeCplasma membrane
GO:0055037 ISS:BHF-UCLCrecycling endosome
GO:0005125 IDA:BHF-UCLFcytokine activity
GO:0042802 IDA:BHF-UCLFidentical protein binding
GO:0002020 IPI:BHF-UCLFprotease binding
GO:0044212 IDA:UniProtKBFtranscription regulatory region DNA binding
GO:0005164 IDA:BHF-UCLFtumor necrosis factor receptor binding
GO:0006919 IDA:UniProtKBPactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0000187 IDA:BHF-UCLPactivation of MAPK activity
GO:0000185 IDA:BHF-UCLPactivation of MAPKKK activity
GO:0006915 TAS:ReactomePapoptotic process
GO:0097190 TAS:ReactomePapoptotic signaling pathway
GO:0019722 IEA:EnsemblPcalcium-mediated signaling
GO:0001775 IEA:EnsemblPcell activation
GO:0071230 IEA:EnsemblPcellular response to amino acid stimulus
GO:0071316 IDA:UniProtKBPcellular response to nicotine
GO:0071407 IDA:UniProtKBPcellular response to organic cyclic compound
GO:0002439 IMP:BHF-UCLPchronic inflammatory response to antigenic stimulus
GO:0050830 IEA:EnsemblPdefense response to Gram-positive bacterium
GO:0050966 IEA:EnsemblPdetection of mechanical stimulus involved in sensory perception of pain
GO:0048566 IEP:DFLATPembryonic digestive tract development
GO:0060664 IEA:EnsemblPepithelial cell proliferation involved in salivary gland morphogenesis
GO:0030198 IEA:EnsemblPextracellular matrix organization
GO:0097191 IDA:UniProtKBPextrinsic apoptotic signaling pathway
GO:0008625 IDA:UniProtKBPextrinsic apoptotic signaling pathway via death domain receptors
GO:0006006 IEA:EnsemblPglucose metabolic process
GO:0006959 IEA:EnsemblPhumoral immune response
GO:0006954 IDA:UniProtKBPinflammatory response
GO:0008630 IEA:EnsemblPintrinsic apoptotic signaling pathway in response to DNA damage
GO:0007254 IEA:EnsemblPJNK cascade
GO:0050901 IDA:BHF-UCLPleukocyte tethering or rolling
GO:0031663 IDA:UniProtKBPlipopolysaccharide-mediated signaling pathway
GO:0000165 IMP:UniProtKBPMAPK cascade
GO:0097527 IDA:UniProtKBPnecroptotic signaling pathway
GO:0010693 IEA:EnsemblPnegative regulation of alkaline phosphatase activity
GO:0061048 IDA:UniProtKBPnegative regulation of branching involved in lung morphogenesis
GO:0008285 IEA:EnsemblPnegative regulation of cell proliferation
GO:0002740 IDA:BHF-UCLPnegative regulation of cytokine secretion involved in immune response
GO:2001240 IDA:BHF-UCLPnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0045599 NAS:BHF-UCLPnegative regulation of fat cell differentiation
GO:0010629 IDA:UniProtKBPnegative regulation of gene expression
GO:0046325 IEA:EnsemblPnegative regulation of glucose import
GO:0044130 IEA:EnsemblPnegative regulation of growth of symbiont in host
GO:0032715 IDA:BHF-UCLPnegative regulation of interleukin-6 production
GO:0002037 IEA:EnsemblPnegative regulation of L-glutamate transport
GO:0050995 IDA:BHF-UCLPnegative regulation of lipid catabolic process
GO:0010888 NAS:BHF-UCLPnegative regulation of lipid storage
GO:0045668 IEA:EnsemblPnegative regulation of osteoblast differentiation
GO:0043242 IDA:UniProtKBPnegative regulation of protein complex disassembly
GO:0045892 IDA:UniProtKBPnegative regulation of transcription, DNA-templated
GO:0000122 IDA:UniProtKBPnegative regulation of transcription from RNA polymerase II promoter
GO:0045071 IDA:BHF-UCLPnegative regulation of viral genome replication
GO:0030316 IEA:EnsemblPosteoclast differentiation
GO:0045760 IEA:EnsemblPpositive regulation of action potential
GO:0043065 IDA:UniProtKBPpositive regulation of apoptotic process
GO:0060559 IDA:BHF-UCLPpositive regulation of calcidiol 1-monooxygenase activity
GO:0045080 IDA:BHF-UCLPpositive regulation of chemokine biosynthetic process
GO:2000343 IDA:BHF-UCLPpositive regulation of chemokine (C-X-C motif) ligand 2 production
GO:0032722 IDA:BHF-UCLPpositive regulation of chemokine production
GO:0002876 IEA:EnsemblPpositive regulation of chronic inflammatory response to antigenic stimulus
GO:0043280 IDA:UniProtKBPpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0001819 IDA:BHF-UCLPpositive regulation of cytokine production
GO:0050715 IDA:BHF-UCLPpositive regulation of cytokine secretion
GO:0070374 NAS:BHF-UCLPpositive regulation of ERK1 and ERK2 cascade
GO:0031622 ISS:BHF-UCLPpositive regulation of fever generation
GO:0010628 IDA:AgBasePpositive regulation of gene expression
GO:0051798 IEA:EnsemblPpositive regulation of hair follicle development
GO:0034116 IDA:BHF-UCLPpositive regulation of heterotypic cell-cell adhesion
GO:0002925 IEA:EnsemblPpositive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0043123 IDA:BHF-UCLPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032729 IEA:EnsemblPpositive regulation of interferon-gamma production
GO:0032741 IEA:EnsemblPpositive regulation of interleukin-18 production
GO:0032755 IEA:EnsemblPpositive regulation of interleukin-6 production
GO:0045416 IDA:BHF-UCLPpositive regulation of interleukin-8 biosynthetic process
GO:0043507 IDA:UniProtKBPpositive regulation of JUN kinase activity
GO:0043406 IDA:UniProtKBPpositive regulation of MAP kinase activity
GO:0051044 IDA:BHF-UCLPpositive regulation of membrane protein ectodomain proteolysis
GO:0045840 IEA:EnsemblPpositive regulation of mitosis
GO:0071677 NAS:BHF-UCLPpositive regulation of mononuclear cell migration
GO:0043525 IEA:EnsemblPpositive regulation of neuron apoptotic process
GO:0051533 IDA:MGIPpositive regulation of NFAT protein import into nucleus
GO:0042346 IDA:BHF-UCLPpositive regulation of NF-kappaB import into nucleus
GO:0051092 IDA:UniProtKBPpositive regulation of NF-kappaB transcription factor activity
GO:0045429 IDA:BHF-UCLPpositive regulation of nitric oxide biosynthetic process
GO:0045672 IDA:BHF-UCLPpositive regulation of osteoclast differentiation
GO:0033138 IDA:BHF-UCLPpositive regulation of peptidyl-serine phosphorylation
GO:0071803 IDA:BHF-UCLPpositive regulation of podosome assembly
GO:0043068 IDA:UniProtKBPpositive regulation of programmed cell death
GO:0031334 IDA:BHF-UCLPpositive regulation of protein complex assembly
GO:0043243 IDA:UniProtKBPpositive regulation of protein complex disassembly
GO:0051897 IEA:EnsemblPpositive regulation of protein kinase B signaling
GO:2000010 IDA:BHF-UCLPpositive regulation of protein localization to cell surface
GO:0001934 IDA:UniProtKBPpositive regulation of protein phosphorylation
GO:0051222 IDA:BHF-UCLPpositive regulation of protein transport
GO:0051091 IDA:BHF-UCLPpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0048661 IDA:BHF-UCLPpositive regulation of smooth muscle cell proliferation
GO:0050806 IEA:EnsemblPpositive regulation of synaptic transmission
GO:0045893 IDA:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0045994 IEA:EnsemblPpositive regulation of translational initiation by iron
GO:0060557 IDA:BHF-UCLPpositive regulation of vitamin D biosynthetic process
GO:0000060 IDA:UniProtKBPprotein import into nucleus, translocation
GO:0043491 IMP:UniProtKBPprotein kinase B signaling
GO:0032800 IDA:BHF-UCLPreceptor biosynthetic process
GO:0060693 IEA:EnsemblPregulation of branching involved in salivary gland morphogenesis
GO:0043122 IDA:BHF-UCLPregulation of I-kappaB kinase/NF-kappaB signaling
GO:0051023 IEA:EnsemblPregulation of immunoglobulin secretion
GO:0050796 IDA:BHF-UCLPregulation of insulin secretion
GO:2000377 IEA:EnsemblPregulation of reactive oxygen species metabolic process
GO:0014823 IEA:EnsemblPresponse to activity
GO:0042493 IEA:EnsemblPresponse to drug
GO:0051384 IDA:BHF-UCLPresponse to glucocorticoid
GO:1990268 IEA:EnsemblPresponse to gold nanoparticle
GO:0001666 IEA:EnsemblPresponse to hypoxia
GO:0009314 IEA:EnsemblPresponse to radiation
GO:0009651 TAS:BHF-UCLPresponse to salt stress
GO:0009615 IDA:BHF-UCLPresponse to virus
GO:0030730 IDA:BHF-UCLPsequestering of triglyceride
GO:0003009 IEA:EnsemblPskeletal muscle contraction
GO:0006927 IDA:BHF-UCLPtransformed cell apoptotic process
GO:0033209 IMP:BHF-UCLPtumor necrosis factor-mediated signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_1619Death Receptor Signalling
REACT_111045Developmental Biology
REACT_1059Extrinsic Pathway
REACT_268456Programmed Cell Death
REACT_1432TNF signaling
REACT_27161Transcriptional regulation of white adipocyte differentiation
SMP Pathway Links
SMP IDDescription
SMP00358Fc Epsilon Receptor I Signaling in Mast Cells
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