MGP Database

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MGP003160

Ontology/Pathway Information

Entrez Gene ID7128
Gene Nametumor necrosis factor, alpha-induced protein 3
Gene Symbol TNFAIP3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005813 IDA:HPACcentrosome
GO:0005737 IDA:HPACcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005764 IEA:UniProtKB-SubCellClysosome
GO:0005634 IDA:HGNCCnucleus
GO:0003677 IEA:UniProtKB-KWFDNA binding
GO:0016874 IEA:UniProtKB-KWFligase activity
GO:0002020 IPI:BHF-UCLFprotease binding
GO:0043621 IDA:BHF-UCLFprotein self-association
GO:0043130 IPI:BHF-UCLFubiquitin binding
GO:0004842 IDA:UniProtKBFubiquitin-protein transferase activity
GO:0004843 IDA:UniProtKBFubiquitin-specific protease activity
GO:0004221 IMP:UniProtKBFubiquitin thiolesterase activity
GO:0008270 IEA:InterProFzinc ion binding
GO:0006915 IEA:UniProtKB-KWPapoptotic process
GO:0001922 ISS:BHF-UCLPB-1 B cell homeostasis
GO:0070301 ISS:UniProtKBPcellular response to hydrogen peroxide
GO:0071222 IDA:BHF-UCLPcellular response to lipopolysaccharide
GO:0006954 IEA:UniProtKB-KWPinflammatory response
GO:0045087 TAS:ReactomePinnate immune response
GO:0050869 ISS:BHF-UCLPnegative regulation of B cell activation
GO:0045779 NAS:BHF-UCLPnegative regulation of bone resorption
GO:2000349 IMP:BHF-UCLPnegative regulation of CD40 signaling pathway
GO:2000352 IDA:BHF-UCLPnegative regulation of endothelial cell apoptotic process
GO:1902042 IDA:BHF-UCLPnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0043124 IDA:UniProtKBPnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050728 ISS:BHF-UCLPnegative regulation of inflammatory response
GO:0045824 ISS:UniProtKBPnegative regulation of innate immune response
GO:0032703 IMP:BHF-UCLPnegative regulation of interleukin-2 production
GO:0032715 ISS:BHF-UCLPnegative regulation of interleukin-6 production
GO:0032088 IDA:BHF-UCLPnegative regulation of NF-kappaB transcription factor activity
GO:0090291 NAS:BHF-UCLPnegative regulation of osteoclast proliferation
GO:0031397 IDA:BHF-UCLPnegative regulation of protein ubiquitination
GO:0048662 IDA:BHF-UCLPnegative regulation of smooth muscle cell proliferation
GO:0034136 NAS:BHF-UCLPnegative regulation of toll-like receptor 2 signaling pathway
GO:0034140 IDA:BHF-UCLPnegative regulation of toll-like receptor 3 signaling pathway
GO:0034144 NAS:BHF-UCLPnegative regulation of toll-like receptor 4 signaling pathway
GO:0032720 ISS:BHF-UCLPnegative regulation of tumor necrosis factor production
GO:0032480 TAS:ReactomePnegative regulation of type I interferon production
GO:0035872 TAS:ReactomePnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0070423 TAS:ReactomePnucleotide-binding oligomerization domain containing signaling pathway
GO:0045732 IDA:BHF-UCLPpositive regulation of protein catabolic process
GO:0016579 TAS:BHF-UCLPprotein deubiquitination
GO:0035871 IDA:UniProtKBPprotein K11-linked deubiquitination
GO:0071108 IDA:UniProtKBPprotein K48-linked deubiquitination
GO:0070936 IDA:UniProtKBPprotein K48-linked ubiquitination
GO:0070536 IDA:UniProtKBPprotein K63-linked deubiquitination
GO:0051259 NAS:BHF-UCLPprotein oligomerization
GO:0050691 NAS:BHF-UCLPregulation of defense response to virus by host
GO:0002634 ISS:BHF-UCLPregulation of germinal center formation
GO:0061043 NAS:BHF-UCLPregulation of vascular wound healing
GO:0002237 IDA:BHF-UCLPresponse to molecule of bacterial origin
GO:0072573 IMP:BHF-UCLPtolerance induction to lipopolysaccharide
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_25271Negative regulators of RIG-I/MDA5 signaling
REACT_75776NOD1/2 Signaling Pathway
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
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