MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003163

UniProt Annotations

Entry Information
Gene Nametroponin I type 1 (skeletal, slow)
Protein EntryTNNI1_HUMAN
UniProt IDP19237
SpeciesHuman
Comments
Comment typeDescription
FunctionTroponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
SimilarityBelongs to the troponin I family. {ECO:0000305}.
SubunitBinds to actin and tropomyosin.
Tissue SpecificityHighest levels observed in human skeletal muscle (e.g. gastrocnemious muscle), differentiated cultures of primary human muscle cells and rhabdomyosarcoma cells cultured in low serum medium. Expressed in C2 muscle cell myoblasts and myotubes. {ECO:0000269|PubMed:2365354, ECO:0000269|PubMed:8144655}.
  logo