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MGP003167

Record overview

MGPD IDMGP003167
Gene ID7139
SpeciesHomo sapiens (Human)
Gene Nametroponin T type 2 (cardiac)
Gene Symbol TNNT2
SynonymsCMH2; RCM3; TnTC; cTnT; CMD1D; CMPD2; LVNC6;
Alternate namestroponin T, cardiac muscle; cardiomyopathy, dilated 1D (autosomal dominant); cardiomyopathy, hypertrophic 2; troponin T2, cardiac;
Chromosome1
Map Location1q32
SummaryThe protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for TNNT2

Proteins

troponin T, cardiac muscle isoform 1
Refseq ID:NP_000355
Protein GI:48255877
UniProt ID:P45379
mRNA ID:NM_000364
Length:295
RefSeq Status:
MSDIEEVVEEYEEEEQEEAAVEEEEDWREDEDEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDI
HRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQK
TERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK
 
troponin T, cardiac muscle isoform 2
Refseq ID:NP_001263276
Protein GI:446715782
UniProt ID:P45379
mRNA ID:NM_001276347
Length:288
RefSeq Status:
MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLN
ELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGK
RQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK
 
troponin T, cardiac muscle isoform 2
Refseq ID:NP_001001430
Protein GI:48255879
UniProt ID:P45379
mRNA ID:NM_001001430
Length:288
RefSeq Status:
Protein sequence is identical to GI:446715782 (mRNA isoform)
 
troponin T, cardiac muscle isoform 3
Refseq ID:NP_001001431
Protein GI:48255881
UniProt ID:P45379
mRNA ID:NM_001001431
Length:285
RefSeq Status:
MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLN
ELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQT
EREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK
 
troponin T, cardiac muscle isoform 4
Refseq ID:NP_001001432
Protein GI:48255883
UniProt ID:P45379
mRNA ID:NM_001001432
Length:282
RefSeq Status:
MSDIEEVVEEYEEEEQEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQAL
IEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKAQTERKSGKRQTERE
KKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK
 
troponin T, cardiac muscle isoform 5
Refseq ID:NP_001263274
Protein GI:446715147
UniProt ID:P45379
mRNA ID:NM_001276345
Length:298
RefSeq Status:
MSDIEEVVEEYEEEEQEEAAVEEEEDWREDEDEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDI
HRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQK
QAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK
 
troponin T, cardiac muscle isoform 6
Refseq ID:NP_001263275
Protein GI:446715553
UniProt ID:P45379
mRNA ID:NM_001276346
Length:255
RefSeq Status:
MSDIEEVVEEYEEEEQEEAAVEEEEDWREDEDEQEEAAEEDAEAEAETEETRAEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDERR
RAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKA
KELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK
 
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