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MGP003168

Record overview

MGPD IDMGP003168
Gene ID7140
SpeciesHomo sapiens (Human)
Gene Nametroponin T type 3 (skeletal, fast)
Gene Symbol TNNT3
SynonymsTNTF;
Alternate namestroponin T, fast skeletal muscle; beta TnTF; beta-TnTF; fTnT; fast skeletal muscle troponin T; troponin-T3, skeletal, fast;
Chromosome11
Map Location11p15.5
SummaryThe binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009]
OrthologsView orthologs and multiple alignments for TNNT3

Proteins

troponin T, fast skeletal muscle isoform 1
Refseq ID:NP_006748
Protein GI:5803203
UniProt ID:P45378
mRNA ID:NM_006757
Length:258
RefSeq Status:
MSDEEVEQVEEQYEEEEEAQEEEEVQEDTAEEDAEEEKPRPKLTAPKIPEGEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRR
AERAEQQRIRAEKERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKILAERRKPLNIDHLGEDKLRDKA
KELWETLHQLEIDKFEFGEKLKRQKYDITTLRSRIDQAQKHSKKAGTPAKGKVGGRWK
 
troponin T, fast skeletal muscle isoform 2
Refseq ID:NP_001036246
Protein GI:112789538
UniProt ID:P45378
mRNA ID:NM_001042781
Length:256
RefSeq Status:
MSDEEVEQVEEQYEEEEEAQEEAAEVHEEVHEPEEKPRPKLTAPKIPEGEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAE
RAEQQRIRAEKERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKILAERRKPLNIDHLGEDKLRDKAKE
LWETLHQLEIDKFEFGEKLKRQKYDITTLRSRIDQAQKHSKKAGTPAKGKVGGRWK
 
troponin T, fast skeletal muscle isoform 3
Refseq ID:NP_001036245
Protein GI:112789536
UniProt ID:P45378
mRNA ID:NM_001042780
Length:250
RefSeq Status:
MSDEEVEQVEEQYEEEEEAQEEEEVQEEEKPRPKLTAPKIPEGEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQR
IRAEKERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKILAERRKPLNIDHLGEDKLRDKAKELWETLH
QLEIDKFEFGEKLKRQKYDIMNVRARVQMLAKFSKKAGTPAKGKVGGRWK
 
troponin T, fast skeletal muscle isoform 4
Refseq ID:NP_001036247
Protein GI:112789541
UniProt ID:P45378
mRNA ID:NM_001042782
Length:250
RefSeq Status:
MSDEEVEQVEEQYEEEEEAQEEEEVQEEEKPRPKLTAPKIPEGEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQR
IRAEKERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKILAERRKPLNIDHLGEDKLRDKAKELWETLH
QLEIDKFEFGEKLKRQKYDITTLRSRIDQAQKHSKKAGTPAKGKVGGRWK
 
troponin T, fast skeletal muscle isoform 4
Refseq ID:NP_001284575
Protein GI:663071012
UniProt ID:P45378
mRNA ID:NM_001297646
Length:250
RefSeq Status:
Protein sequence is identical to GI:112789541 (mRNA isoform)
 
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