MGP Database

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MGP003172

Ontology/Pathway Information

Entrez Gene ID7153
Gene Nametopoisomerase (DNA) II alpha 170kDa
Gene Symbol TOP2A
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0000793 IEA:EnsemblCcondensed chromosome
GO:0005737 IEA:UniProtKB-SubCellCcytoplasm
GO:0009330 IDA:UniProtKBCDNA topoisomerase complex (ATP-hydrolyzing)
GO:0005730 IDA:UniProtKBCnucleolus
GO:0005654 IDA:UniProtKBCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0043234 IDA:UniProtKBCprotein complex
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0003682 IDA:UniProtKBFchromatin binding
GO:0003677 IDA:UniProtKBFDNA binding
GO:0008301 IDA:UniProtKBFDNA binding, bending
GO:0008094 IDA:UniProtKBFDNA-dependent ATPase activity
GO:0003918 IDA:UniProtKBFDNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0008144 IDA:UniProtKBFdrug binding
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0042826 IPI:UniProtKBFhistone deacetylase binding
GO:0000287 IDA:UniProtKBFmagnesium ion binding
GO:0044822 IDA:UniProtKBFpoly(A) RNA binding
GO:0008022 IPI:UniProtKBFprotein C-terminus binding
GO:0046982 IPI:UniProtKBFprotein heterodimerization activity
GO:0042803 IPI:UniProtKBFprotein homodimerization activity
GO:0005080 IPI:UniProtKBFprotein kinase C binding
GO:0043130 IMP:UniProtKBFubiquitin binding
GO:0030263 IDA:UniProtKBPapoptotic chromosome condensation
GO:0006200 IDA:GOCPATP catabolic process
GO:0006974 IDA:UniProtKBPcellular response to DNA damage stimulus
GO:0007059 IMP:UniProtKBPchromosome segregation
GO:0006266 IDA:UniProtKBPDNA ligation
GO:0006265 IDA:UniProtKBPDNA topological change
GO:0006268 IBA:GO_CentralPDNA unwinding involved in DNA replication
GO:0040016 IEA:EnsemblPembryonic cleavage
GO:0002244 IEA:EnsemblPhematopoietic progenitor cell differentiation
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0044774 IBA:GO_CentralPmitotic DNA integrity checkpoint
GO:0006312 IBA:GO_CentralPmitotic recombination
GO:0043065 IDA:UniProtKBPpositive regulation of apoptotic process
GO:0045870 IMP:UniProtKBPpositive regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045944 IEA:EnsemblPpositive regulation of transcription from RNA polymerase II promoter
GO:0045070 IMP:UniProtKBPpositive regulation of viral genome replication
GO:0000712 IBA:GO_CentralPresolution of meiotic recombination intermediates
GO:0000819 IBA:GO_CentralPsister chromatid segregation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_115566Cell Cycle
REACT_152Cell Cycle, Mitotic
REACT_111214G0 and Early G1
REACT_21267Mitotic G1-G1/S phases
SMP Pathway Links
SMP IDDescription
SMP00442Etoposide Action Pathway
SMP00601Etoposide Metabolism Pathway
SMP00443Teniposide Action Pathway
SMP00602Teniposide Metabolism Pathway
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