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MGP003177

UniProt Annotations

Entry Information
Gene Nametumor protein D52
Protein EntryTPD52_HUMAN
UniProt IDP55327
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=8; Name=1; IsoId=P55327-1; Sequence=Displayed; Name=2; IsoId=P55327-2; Sequence=VSP_035751; Name=3; Synonyms=N8L; IsoId=P55327-3; Sequence=VSP_037378; Name=4; IsoId=P55327-4; Sequence=VSP_035751, VSP_043510; Note=No experimental confirmation available.; Name=5; Synonyms=PrLZ-238; IsoId=P55327-5; Sequence=VSP_047719; Name=6; Synonyms=PrLZ-247; IsoId=P55327-6; Sequence=VSP_043510; Name=7; Synonyms=PrLZ-233; IsoId=P55327-7; Sequence=VSP_047720; Name=8; Synonyms=PrLZ-151; IsoId=P55327-8; Sequence=VSP_047718; Note=Interacts only with YWHAB and YWHAQ among 14-3-3 proteins.;
Developmental StageIsoform 2 is expressed at lower levels in fetal brain and kidney than in adult brain and kidney. {ECO:0000269|PubMed:8632896}.
InteractionQ62393:Tpd52 (xeno); NbExp=2; IntAct=EBI-782581, EBI-782591; Q16890:TPD52L1; NbExp=3; IntAct=EBI-782581, EBI-717470;
Sequence CautionSequence=BAD97351.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the TPD52 family. {ECO:0000305}.
SubunitForms a homodimer or heterodimer with other members of the family. All isoforms interact with several 14-3-3 proteins.
Tissue SpecificityIsoform 2 is expressed in colon, breast, prostate, pancreas and kidney tumor cell lines. Isoform 2 is expressed at high levels in kidney, prostate, brain, small intestine and pancreas, at moderate levels in placenta and colon, at low levels in lung, liver and heart, and at very low levels in spleen, thymus, peripheral mononuclear blood cells, testis and ovary. {ECO:0000269|PubMed:8632896}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/TPD52ID42676ch8q21.html";
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