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MGP003180

Record overview

MGPD IDMGP003180
Gene ID7167
SpeciesHomo sapiens (Human)
Gene Nametriosephosphate isomerase 1
Gene Symbol TPI1
SynonymsTIM; TPI; TPID; HEL-S-49;
Alternate namestriosephosphate isomerase; epididymis secretory protein Li 49; triose-phosphate isomerase;
Chromosome12
Map Location12p13
EC Number5.3.1.1
SummaryThis gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
OrthologsView orthologs and multiple alignments for TPI1

Proteins

triosephosphate isomerase isoform 1
Refseq ID:NP_000356
Protein GI:4507645
UniProt ID:P60174
mRNA ID:NM_000365
Length:249
RefSeq Status:
MAPSRKFFVGGNWKMNGRKQSLGELIGTLNAAKVPADTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIKDCGATWVVLGHSERR
HVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDA
VAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPEFVDIINAKQ
 
triosephosphate isomerase isoform 2
Refseq ID:NP_001152759
Protein GI:226529917
UniProt ID:P60174
mRNA ID:NM_001159287
Length:286
RefSeq Status:
MAEDGEEAEFHFAALYISGQWPRLRADTDLQRLGSSAMAPSRKFFVGGNWKMNGRKQSLGELIGTLNAAKVPADTEVVCAPPTAYIDFARQKLDPKIAVA
AQNCYKVTNGAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVL
AYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPEFVDIINAKQ
 
triosephosphate isomerase isoform 3
Refseq ID:NP_001244955
Protein GI:384475517
UniProt ID:P60174
mRNA ID:NM_001258026
Length:167
RefSeq Status:
MIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTATPQQA
QEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPEFVDIINAKQ
 
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