MGP Database

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MGP003182

Record overview

MGPD IDMGP003182
Gene ID7169
SpeciesHomo sapiens (Human)
Gene Nametropomyosin 2 (beta)
Gene Symbol TPM2
SynonymsDA1; DA2B; NEM4; TMSB; AMCD1; HEL-S-273;
Alternate namestropomyosin beta chain; epididymis secretory protein Li 273; nemaline myopathy type 4;
Chromosome9
Map Location9p13
SummaryThis gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
OrthologsView orthologs and multiple alignments for TPM2

Proteins

tropomyosin beta chain isoform Tpm2.1sm/cy
Refseq ID:NP_998839
Protein GI:47519616
UniProt ID:P07951
mRNA ID:NM_213674
Length:284
RefSeq Status:
MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATDAEADVASLNRRIQLVEEELD
RAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESRARQLEEELRTM
DQALKSLMASEEEYSTKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEETLASAKEENVEIHQTLDQTLLELNNL
 
tropomyosin beta chain isoform Tpm2.2st
Refseq ID:NP_003280
Protein GI:42476296
UniProt ID:P07951
mRNA ID:NM_003289
Length:284
RefSeq Status:
MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATDAEADVASLNRRIQLVEEELD
RAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESKCGDLEEELKIV
TNNLKSLEAQADKYSTKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKYKAISEELDNALNDITSL
 
tropomyosin beta chain isoform Tpm2.3
Refseq ID:NP_001288155
Protein GI:669033275
UniProt ID:Q5TCU3
mRNA ID:NM_001301226
Length:284
RefSeq Status:
MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATDAEADVASLNRRIQLVEEELD
RAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESKCGDLEEELKIV
TNNLKSLEAQADKYSTKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEETLASAKEENVEIHQTLDQTLLELNNL
 
tropomyosin beta chain isoform Tpm2.4
Refseq ID:NP_001288156
Protein GI:669033277
UniProt ID:A7XZE4
mRNA ID:NM_001301227
Length:284
RefSeq Status:
MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATDAEADVASLNRRIQLVEEELD
RAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESRARQLEEELRTM
DQALKSLMASEEEYSTKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKYKAISEELDNALNDITSL
 
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