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MGP003183

Record overview

MGPD IDMGP003183
Gene ID7170
SpeciesHomo sapiens (Human)
Gene Nametropomyosin 3
Gene Symbol TPM3
SynonymsTM3; TM5; TRK; CFTD; NEM1; TM-5; TM30; CAPM1; TM30nm; TPMsk3; hscp30; HEL-189; HEL-S-82p; OK/SW-cl.5;
Alternate namestropomyosin alpha-3 chain; alpha-tropomyosin, slow skeletal; cytoskeletal tropomyosin TM30; epididymis luminal protein 189; epididymis secretory sperm binding protein Li 82p; heat-stable cytoskeletal protein 30 kDa; tropomyosin gamma; tropomyosin-5;
Chromosome1
Map Location1q21.2
SummaryThis gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
OrthologsView orthologs and multiple alignments for TPM3

Proteins

tropomyosin alpha-3 chain isoform 6
Refseq ID:NP_001265117
Protein GI:499137516
UniProt ID:B4DQ80
mRNA ID:NM_001278188
Length:182
RefSeq Status:
MMQRSELSASSEKLREKGGPGNRGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQ
NLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLNEM
 
tropomyosin alpha-3 chain isoform 8
Refseq ID:NP_001265119
Protein GI:499137520
UniProt ID:
mRNA ID:NM_001278190
Length:227
RefSeq Status:
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALK
DEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKAETRAEFAERSVAKLEKTIDDLE
DKLKCTKEEHLCTQRMLDQTLLDLNEM
 
tropomyosin alpha-3 chain isoform 9
Refseq ID:NP_001265120
Protein GI:499137522
UniProt ID:P06753
mRNA ID:NM_001278191
Length:158
RefSeq Status:
MKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIK
ILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLNEM
 
tropomyosin alpha-3 chain isoform Tpm3.12st
Refseq ID:NP_689476
Protein GI:114155140
UniProt ID:P06753
mRNA ID:NM_152263
Length:285
RefSeq Status:
MMEAIKKKMQMLKLDKENALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVASLNRRIQLVEEEL
DRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN
VTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDELYAQKLKYKAISEELDHALNDMTSI
 
tropomyosin alpha-3 chain isoform Tpm3.1cy
Refseq ID:NP_705935
Protein GI:24119203
UniProt ID:P06753
mRNA ID:NM_153649
Length:248
RefSeq Status:
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALK
DEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAE
TRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLNEM
 
tropomyosin alpha-3 chain isoform Tpm3.2cy
Refseq ID:NP_001036816
Protein GI:114155144
UniProt ID:P06753
mRNA ID:NM_001043351
Length:248
RefSeq Status:
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALK
DEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAE
TRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLNEM
 
tropomyosin alpha-3 chain isoform Tpm3.4cy
Refseq ID:NP_001036818
Protein GI:114155148
UniProt ID:P06753
mRNA ID:NM_001043353
Length:247
RefSeq Status:
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALK
DEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAE
TRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKLTLHDLCD
 
tropomyosin alpha-3 chain isoform Tpm3.5cy
Refseq ID:NP_001265118
Protein GI:499137518
UniProt ID:P06753
mRNA ID:NM_001278189
Length:248
RefSeq Status:
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALK
DEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAE
TRAEFAERSVAKLEKTIDDLEDELYAQKLKYKAISEELDHALNDMTSI
 
tropomyosin alpha-3 chain isoform Tpm3.7cy
Refseq ID:NP_001036817
Protein GI:114155146
UniProt ID:P06753
mRNA ID:NM_001043352
Length:247
RefSeq Status:
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALK
DEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAE
TRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKLTLHDLCD
 
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