MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003184

Record overview

MGPD IDMGP003184
Gene ID7171
SpeciesHomo sapiens (Human)
Gene Nametropomyosin 4
Gene Symbol TPM4
SynonymsHEL-S-108;
Alternate namestropomyosin alpha-4 chain; TM30p1; epididymis secretory protein Li 108; tropomyosin-4;
Chromosome19
Map Location19p13.1
SummaryThis gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
OrthologsView orthologs and multiple alignments for TPM4

Proteins

tropomyosin alpha-4 chain isoform Tpm4.1cy
Refseq ID:NP_001138632
Protein GI:223555975
UniProt ID:P67936
mRNA ID:NM_001145160
Length:284
RefSeq Status:
MEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEKLELTEKKASDAEGDVAALNRRIQLVEEELD
RAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNV
TNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQTLNELNCI
 
tropomyosin alpha-4 chain isoform Tpm4.2cy
Refseq ID:NP_003281
Protein GI:4507651
UniProt ID:P67936
mRNA ID:NM_003290
Length:248
RefSeq Status:
MAGLNSLEAVKRKIQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMK
DEEKMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAE
TRAEFAERTVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQTLNELNCI
 
  logo