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MGP003185

Record overview

MGPD IDMGP003185
Gene ID7172
SpeciesHomo sapiens (Human)
Gene Namethiopurine S-methyltransferase
Gene Symbol TPMT
Alternate namesthiopurine S-methyltransferase; S-adenosyl-L-methionine:thiopurine S-methyltransferase;
Chromosome6
Map Location6p22.3
EC Number2.1.1.67
SummaryThis gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]
OrthologsView orthologs and multiple alignments for TPMT

Proteins

thiopurine S-methyltransferase
Refseq ID:NP_000358
Protein GI:4507653
UniProt ID:P51580
mRNA ID:NM_000367
Length:245
RefSeq Status:
MDGTRTSLDIEEYSDTEVQKNQVLTLEEWQDKWVNGKTAFHQEQGHQLLKKHLDTFLKGKSGLRVFFPLCGKAVEMKWFADRGHSVVGVEISELGIQEFF
TEQNLSYSEEPITEIPGTKVFKSSSGNISLYCCSIFDLPRTNIGKFDMIWDRGALVAINPGDRKCYADTMFSLLGKKFQYLLCVLSYDPTKHPGPPFYVP
HAEIERLFGKICNIRCLEKVDAFEERHKSWGIDCLFEKLYLLTEK
 
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