MGP Database

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MGP003208

Ontology/Pathway Information

Entrez Gene ID7249
Gene Nametuberous sclerosis 2
Gene Symbol TSC2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005901 IEA:EnsemblCcaveola
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005856 IEA:EnsemblCcytoskeleton
GO:0005829 IDA:UniProtKBCcytosol
GO:0030425 IEA:EnsemblCdendrite
GO:0005794 IDA:UniProtKBCGolgi apparatus
GO:0030426 IEA:EnsemblCgrowth cone
GO:0016020 IDA:UniProtKBCmembrane
GO:0043025 IEA:EnsemblCneuronal cell body
GO:0005634 IDA:UniProtKBCnucleus
GO:0048471 IDA:UniProtKBCperinuclear region of cytoplasm
GO:0033596 IDA:UniProtKBCTSC1-TSC2 complex
GO:0005096 IDA:UniProtKBFGTPase activator activity
GO:0019902 IDA:UniProtKBFphosphatase binding
GO:0042803 IPI:UniProtKBFprotein homodimerization activity
GO:0006953 IEA:EnsemblPacute-phase response
GO:0007050 TAS:ReactomePcell cycle arrest
GO:0030030 IEA:EnsemblPcell projection organization
GO:0006897 TAS:ProtIncPendocytosis
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0007507 ISS:UniProtKBPheart development
GO:0045087 TAS:ReactomePinnate immune response
GO:0048009 ISS:UniProtKBPinsulin-like growth factor receptor signaling pathway
GO:0008286 TAS:ReactomePinsulin receptor signaling pathway
GO:0008285 ISS:UniProtKBPnegative regulation of cell proliferation
GO:0045792 IEA:EnsemblPnegative regulation of cell size
GO:0050680 IEA:EnsemblPnegative regulation of epithelial cell proliferation
GO:0046627 IBA:GO_CentralPnegative regulation of insulin receptor signaling pathway
GO:0043407 IEA:EnsemblPnegative regulation of MAP kinase activity
GO:0014067 ISS:UniProtKBPnegative regulation of phosphatidylinositol 3-kinase signaling
GO:0006469 ISS:UniProtKBPnegative regulation of protein kinase activity
GO:0051898 ISS:UniProtKBPnegative regulation of protein kinase B signaling
GO:0032007 IBA:GO_CentralPnegative regulation of TOR signaling
GO:0030178 IBA:GO_CentralPnegative regulation of Wnt signaling pathway
GO:0001843 ISS:UniProtKBPneural tube closure
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0014065 IEA:EnsemblPphosphatidylinositol 3-kinase signaling
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0050918 ISS:UniProtKBPpositive chemotaxis
GO:0032320 IBA:GO_CentralPpositive regulation of Ras GTPase activity
GO:0051291 IEA:EnsemblPprotein heterooligomerization
GO:0051260 IEA:EnsemblPprotein homooligomerization
GO:0006606 ISS:UniProtKBPprotein import into nucleus
GO:0043491 ISS:UniProtKBPprotein kinase B signaling
GO:0008104 ISS:UniProtKBPprotein localization
GO:0051726 IBA:GO_CentralPregulation of cell cycle
GO:0030100 ISS:UniProtKBPregulation of endocytosis
GO:0046626 ISS:UniProtKBPregulation of insulin receptor signaling pathway
GO:0001666 IEA:EnsemblPresponse to hypoxia
GO:0016192 TAS:ProtIncPvesicle-mediated transport
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_12564AKT phosphorylates targets in the cytosol
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_21387Energy dependent regulation of mTOR by LKB1-AMPK
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_12578GAB1 signalosome
REACT_150210IGF1R signaling cascade
REACT_6900Immune System
REACT_6743Inhibition of TSC complex formation by PKB
REACT_6802Innate Immune System
REACT_1195Insulin receptor signalling cascade
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_6838mTOR signalling
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_976PI3K Cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_456PKB-mediated events
REACT_21393Regulation of Rheb GTPase activity by AMPK
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_498Signaling by Insulin receptor
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
SMP Pathway Links
SMP IDDescription
SMP00682Leucine Stimulation on Insulin Signaling
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