MGP Database

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MGP003214

UniProt Annotations

Entry Information
Gene Nametissue specific transplantation antigen P35B
Protein EntryFCL_HUMAN
UniProt IDQ13630
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityGDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-6- deoxy-alpha-D-mannose + NADPH.
FunctionCatalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. {ECO:0000269|PubMed:8910301}.
PathwayNucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.
SimilarityBelongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily. {ECO:0000305}.
SubunitHomodimer. {ECO:0000269|PubMed:23774504, ECO:0000269|PubMed:8910301}.
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