MGP Database

MGP003225

Ontology/Pathway Information

Entrez Gene ID	7294
Gene Name	TXK tyrosine kinase
Gene Symbol	TXK
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IDA:UniProtKB	C	cytoplasm
GO:0031234	IBA:GO_Central	C	extrinsic component of cytoplasmic side of plasma membrane
GO:0005634	IDA:UniProtKB	C	nucleus
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0004715	IBA:GO_Central	F	non-membrane spanning protein tyrosine kinase activity
GO:0000978	IDA:NTNU_SB	F	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	IDA:NTNU_SB	F	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001012	IDA:UniProtKB	F	RNA polymerase II regulatory region DNA binding
GO:0007202	ISS:UniProtKB	P	activation of phospholipase C activity
GO:0002250	ISS:UniProtKB	P	adaptive immune response
GO:0001816	ISS:UniProtKB	P	cytokine production
GO:0032609	IEA:Ensembl	P	interferon-gamma production
GO:0032633	IEA:Ensembl	P	interleukin-4 production
GO:0001865	IEA:Ensembl	P	NK T cell differentiation
GO:0038083	IBA:GO_Central	P	peptidyl-tyrosine autophosphorylation
GO:0060335	IDA:UniProtKB	P	positive regulation of interferon-gamma-mediated signaling pathway
GO:0032729	IDA:UniProtKB	P	positive regulation of interferon-gamma production
GO:0045944	IDA:NTNU_SB	P	positive regulation of transcription from RNA polymerase II promoter
GO:0046777	IDA:UniProtKB	P	protein autophosphorylation
GO:0006468	TAS:ProtInc	P	protein phosphorylation
GO:0042127	IBA:GO_Central	P	regulation of cell proliferation
GO:0006357	IDA:UniProtKB	P	regulation of transcription from RNA polymerase II promoter
GO:0030217	IBA:GO_Central	P	T cell differentiation
GO:0050852	ISS:UniProtKB	P	T cell receptor signaling pathway
GO:0007169	IBA:GO_Central	P	transmembrane receptor protein tyrosine kinase signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_163936	Fc epsilon receptor (FCERI) signaling
REACT_163834	FCERI mediated Ca+2 mobilization
REACT_6900	Immune System
REACT_6802	Innate Immune System