MGP Database

MGP003231

Record overview

MGPD ID	MGP003231
Gene ID	7305
Species	Homo sapiens (Human)
Gene Name	TYRO protein tyrosine kinase binding protein
Gene Symbol	TYROBP
Synonyms	DAP12; KARAP; PLOSL;
Alternate names	TYRO protein tyrosine kinase-binding protein; DNAX-activation protein 12; KAR-associated protein; killer-activating receptor-associated protein;
Chromosome	19
Map Location	19q13.1
Summary	This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]
Orthologs	View orthologs and multiple alignments for TYROBP

Proteins

TYRO protein tyrosine kinase-binding protein isoform 1 precursor

Refseq ID:	NP_003323
Protein GI:	4507755
UniProt ID:	O43914
mRNA ID:	NM_003332
Length:	113
RefSeq Status:

`MGGLEPCSRLLLLPLLLAVSGLRPVQAQAQSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEAATRKQRITETESPYQELQGQRSD VYSDLNTQRPYYK`

sig_peptide: 1..27
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2818
peptide sequence: 
MGGLEPCSRLLLLPLLLAVSGLRPVQA

mat_peptide: 28..112
product: TYRO protein tyrosine kinase-binding protein isoform 2
calculated_mol_wt: 9309
peptide sequence: 
QAQSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK

sig_peptide: 1..27
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2818
peptide sequence: 
MGGLEPCSRLLLLPLLLAVSGLRPVQA

mat_peptide: 22..113
product: TYRO protein tyrosine kinase-binding protein
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (O43914.1)
calculated_mol_wt: 10045
peptide sequence: 
LRPVQAQAQSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEAATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK

mat_peptide: 28..113
product: TYRO protein tyrosine kinase-binding protein isoform 1
calculated_mol_wt: 9380
peptide sequence: 
QAQSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEAATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK

TYRO protein tyrosine kinase-binding protein isoform 2 precursor

Refseq ID:	NP_937758
Protein GI:	38158005
UniProt ID:	O43914
mRNA ID:	NM_198125
Length:	112
RefSeq Status:

`MGGLEPCSRLLLLPLLLAVSGLRPVQAQAQSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEATRKQRITETESPYQELQGQRSDV YSDLNTQRPYYK`

sig_peptide: 1..27
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2818
peptide sequence: 
MGGLEPCSRLLLLPLLLAVSGLRPVQA

mat_peptide: 28..112
product: TYRO protein tyrosine kinase-binding protein isoform 2
calculated_mol_wt: 9309
peptide sequence: 
QAQSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK

TYRO protein tyrosine kinase-binding protein isoform 3 precursor

Refseq ID:	NP_001166985
Protein GI:	291045272
UniProt ID:	O43914
mRNA ID:	NM_001173514
Length:	102
RefSeq Status:

`MGGLEPCSRLLLLPLLLAVSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEAATRKQRITETESPYQELQGQRSDVYSDLNTQRPY YK`

sig_peptide: 1..27
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2818
peptide sequence: 
MGGLEPCSRLLLLPLLLAVSGLRPVQA

mat_peptide: 28..112
product: TYRO protein tyrosine kinase-binding protein isoform 2
calculated_mol_wt: 9309
peptide sequence: 
QAQSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK

sig_peptide: 1..27
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2818
peptide sequence: 
MGGLEPCSRLLLLPLLLAVSGLRPVQA

mat_peptide: 22..113
product: TYRO protein tyrosine kinase-binding protein
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (O43914.1)
calculated_mol_wt: 10045
peptide sequence: 
LRPVQAQAQSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEAATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK

mat_peptide: 28..113
product: TYRO protein tyrosine kinase-binding protein isoform 1
calculated_mol_wt: 9380
peptide sequence: 
QAQSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEAATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK

sig_peptide: 1..22
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2314
peptide sequence: 
MGGLEPCSRLLLLPLLLAVSDC

mat_peptide: 23..102
product: TYRO protein tyrosine kinase-binding protein isoform 3
calculated_mol_wt: 8747
peptide sequence: 
SCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEAATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK

TYRO protein tyrosine kinase-binding protein isoform 4 precursor

Refseq ID:	NP_001166986
Protein GI:	291045274
UniProt ID:	X6RGC9
mRNA ID:	NM_001173515
Length:	101
RefSeq Status:

`MGGLEPCSRLLLLPLLLAVSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEATRKQRITETESPYQELQGQRSDVYSDLNTQRPYY K`

sig_peptide: 1..27
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2818
peptide sequence: 
MGGLEPCSRLLLLPLLLAVSGLRPVQA

mat_peptide: 28..112
product: TYRO protein tyrosine kinase-binding protein isoform 2
calculated_mol_wt: 9309
peptide sequence: 
QAQSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK

sig_peptide: 1..27
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2818
peptide sequence: 
MGGLEPCSRLLLLPLLLAVSGLRPVQA

mat_peptide: 22..113
product: TYRO protein tyrosine kinase-binding protein
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (O43914.1)
calculated_mol_wt: 10045
peptide sequence: 
LRPVQAQAQSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEAATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK

mat_peptide: 28..113
product: TYRO protein tyrosine kinase-binding protein isoform 1
calculated_mol_wt: 9380
peptide sequence: 
QAQSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEAATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK

sig_peptide: 1..22
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2314
peptide sequence: 
MGGLEPCSRLLLLPLLLAVSDC

mat_peptide: 23..102
product: TYRO protein tyrosine kinase-binding protein isoform 3
calculated_mol_wt: 8747
peptide sequence: 
SCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEAATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK

sig_peptide: 1..22
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2314
peptide sequence: 
MGGLEPCSRLLLLPLLLAVSDC

mat_peptide: 23..101
product: TYRO protein tyrosine kinase-binding protein isoform 4
calculated_mol_wt: 8676
peptide sequence: 
SCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK